Review of linear epidermal nevus with oral mucosal involvement - series of five new cases

Introduction:  Linear epidermal nevi are sporadic hamartomatous alterations of the epidermis and superficial dermis that clinically appear as verrucous papules and plaques distributed in a linear pattern following Blaschko's lines. Their extent varies from unilateral involvement (nevus unius la...

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Published in:Oral diseases 2008-03, Vol.14 (2), p.131-137
Main Authors: Haberland-Carrodeguas, C, Allen, CM, Lovas, JGL, Hicks, J, Flaitz, CM, Carlos, R, Stal, S
Format: Article
Language:English
Subjects:
Adolescent
benign epithelial disorders
Child
Child, Preschool
cutaneous
Dentistry
epidermal nevus syndromes
Facial Dermatoses - complications
Facial Dermatoses - pathology
Female
Hamartoma - complications
Hamartoma - pathology
Humans
linear epidermal nevus
Male
Middle Aged
Mouth Diseases - complications
Mouth Diseases - pathology
Mouth Mucosa - pathology
Nevus - complications
Nevus - pathology
oral mucosa
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Summary:Introduction:  Linear epidermal nevi are sporadic hamartomatous alterations of the epidermis and superficial dermis that clinically appear as verrucous papules and plaques distributed in a linear pattern following Blaschko's lines. Their extent varies from unilateral involvement (nevus unius lateris) to extensive bilateral involvement (ichthyosis hystrix). Oral mucosal lesions have rarely been described. Aims:  We review the literature, focusing on the rare intraoral manifestations of linear epidermal nevus. Case series:  We present a series of five new cases with oral mucosal involvement. Four cases had associated cutaneous lesions and one case had oral lesions exclusively. Histopathologic evaluation of lesional tissue in four cases showed hyperkeratosis, acanthosis, epithelial hyperplasia, and papillomatosis. Dental abnormalities, consisting of enamel hypoplasia and congenitally missing teeth, were noted in one patient adjacent to the oral lesions.
ISSN:1354-523X
1601-0825
DOI:10.1111/j.1601-0825.2006.01355.x