Gold-Catalyzed Intermolecular Hetero-Dehydro-Diels−Alder Cycloaddition of Captodative Dienynes with Nitriles:  A New Reaction and Regioselective Direct Access to Pyridines

For the first time, nitriles are used as 2π electron component in a gold-catalyzed intermolecular Hetero-Dehydro-Diels−Alder cycloaddition with captodative enynes leading to the regioselective formation of pyridines.

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Bibliographic Details
Published in:Journal of the American Chemical Society 2008-03, Vol.130 (9), p.2764-2765
Main Authors: Barluenga, José, Fernández-Rodríguez, Manuel Ángel, García-García, Patricia, Aguilar, Enrique
Format: Article
Language:English
Subjects:
Alkynes - chemistry
Catalysis
Crystallization
Cyclization
Gold - chemistry
Molecular Structure
Nitriles - chemistry
Organometallic Compounds - chemistry
Pyridines - chemical synthesis
Pyridines - chemistry
Stereoisomerism
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Description
Summary:For the first time, nitriles are used as 2π electron component in a gold-catalyzed intermolecular Hetero-Dehydro-Diels−Alder cycloaddition with captodative enynes leading to the regioselective formation of pyridines.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja7112917