Current concepts in the pathogenesis of nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized cause of chronic liver disease, representing the leading cause of hepatology referral in some centres. However, its pathophysiology is not completely understood. Insulin resistance is one of the major mechanisms involved in disea...

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Bibliographic Details
Published in:Liver international 2007-05, Vol.27 (4), p.423-433
Main Authors: Méndez-Sánchez, Nahum, Arrese, Marco, Zamora-Valdés, Daniel, Uribe, Misael
Format: Article
Language:English
Subjects:
chronic liver disease
Fatty Acids - metabolism
Fatty Liver - etiology
Humans
Insulin Resistance
Liver - metabolism
Liver - pathology
Metabolic Networks and Pathways
metabolic syndrome
nonalcoholic fatty liver disease
nonalcoholic steatohepatitis
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Summary:Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized cause of chronic liver disease, representing the leading cause of hepatology referral in some centres. However, its pathophysiology is not completely understood. Insulin resistance is one of the major mechanisms involved in disease prevalence and progression. Owing to the lack of an effective pharmacological therapy, recommendations on treatment are scarce and are based mainly on lifestyle changes, including diet and exercise. A review of the current literature on pathogenesis of NAFLD is presented in this article.
ISSN:1478-3223
1478-3231
DOI:10.1111/j.1478-3231.2007.01483.x