Outcomes Attributable to Neonatal Candidiasis

Background. The incidence of candidiasis has increased in neonatal intensive care units, and invasive candidiasis is associated with significant morbidity and mortality. However, few data exist on outcomes directly attributable to neonatal candidiasis. Methods. We estimated the incidence of systemic...

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Bibliographic Details
Published in:Clinical infectious diseases 2007-05, Vol.44 (9), p.1187-1193
Main Authors: Zaoutis, Theoklis E., Heydon, Kateri, Localio, Russell, Walsh, Thomas J., Feudtner, Chris
Format: Article
Language:English
Subjects:
Articles and Commentaries
Biological and medical sciences
Birth Weight
Candidemia
Candidiasis
Candidiasis - epidemiology
Candidiasis - mortality
Clinical outcomes
Correlation analysis
Databases, Factual
Death
Female
Fungal infections
Health care expenditures
Health outcomes
Hospital Costs
Hospitalization
Humans
Incidence
Infant mortality
Infant, Extremely Low Birth Weight
Infant, Newborn
Infants
Infectious diseases
Information attributes
Intensive Care Units, Neonatal - statistics & numerical data
Length of Stay
Male
Medical sciences
Mortality
Newborns
Pediatrics
Risk Assessment
Risk factors
United States - epidemiology
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Summary:Background. The incidence of candidiasis has increased in neonatal intensive care units, and invasive candidiasis is associated with significant morbidity and mortality. However, few data exist on outcomes directly attributable to neonatal candidiasis. Methods. We estimated the incidence of systemic candidiasis in hospitalized neonates within the United States and determined the attributable mortality, length of hospital stay, and associated costs. We used the 2003 Kid's Inpatient Database from the Healthcare Cost and Utilization Project. Systemic candidiasis and comorbidities were defined by International Classification of Diseases, Ninth Revision, Clinical Modification codes. Neonates with uncomplicated births and neonates who died within the first 3 days of life were excluded. We used propensity score methods to balance covariates between the neonates with and neonates without candidiasis. Attributable outcomes were calculated between propensity score—matched neonates with and neonates without candidiasis. Because of the known confounding effect of birth weight, we performed separate propensity score analyses for extremely low birth weight (ELBW) neonates (i.e., neonates weighing
ISSN:1058-4838
1537-6591
DOI:10.1086/513196