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Facial fear processing and psychotic symptoms in schizophrenia: functional magnetic resonance imaging study
The recognition of negative facial affect is impaired in people with schizophrenia. The neural underpinnings of this deficit and its relationship to the symptoms of psychosis are still unclear. To examine the association between positive and negative psychotic symptoms and activation within the amyg...
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| Published in: | British journal of psychiatry 2008-03, Vol.192 (3), p.191-196 |
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| Main Authors: | , , , , , |
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| cites | cdi_FETCH-LOGICAL-c537t-5677431af394f97f116bae63a338e74eebc85f3119381abbe8bdaac6d06e80de3 |
| container_end_page | 196 |
| container_issue | 3 |
| container_start_page | 191 |
| container_title | British journal of psychiatry |
| container_volume | 192 |
| creator | Michalopoulou, Panayiota G. Surguladze, Simon Morley, Lucy A. Giampietro, Vincent P. Murray, Robin M. Shergill, Sukhwinder S. |
| description | The recognition of negative facial affect is impaired in people with schizophrenia. The neural underpinnings of this deficit and its relationship to the symptoms of psychosis are still unclear.
To examine the association between positive and negative psychotic symptoms and activation within the amygdala and extrastriate visual regions of patients with schizophrenia during fearful and neutral facial expression processing.
Functional magnetic resonance imaging was used to measure neural responses to neutral and fearful facial expressions in 11 patients with schizophrenia and 9 healthy volunteers during an implicit emotional task.
No association between amygdala activation and positive symptoms was found; the activation within the left superior temporal gyrus was negatively associated with the negative symptoms of the patients.
Our results indicate an association between impaired extrastriate visual processing of facial fear and negative symptoms, which may underlie the previously reported difficulties of patients with negative symptoms in the recognition of facial fear. |
| doi_str_mv | 10.1192/bjp.bp.106.032649 |
| format | article |
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To examine the association between positive and negative psychotic symptoms and activation within the amygdala and extrastriate visual regions of patients with schizophrenia during fearful and neutral facial expression processing.
Functional magnetic resonance imaging was used to measure neural responses to neutral and fearful facial expressions in 11 patients with schizophrenia and 9 healthy volunteers during an implicit emotional task.
No association between amygdala activation and positive symptoms was found; the activation within the left superior temporal gyrus was negatively associated with the negative symptoms of the patients.
Our results indicate an association between impaired extrastriate visual processing of facial fear and negative symptoms, which may underlie the previously reported difficulties of patients with negative symptoms in the recognition of facial fear.</description><identifier>ISSN: 0007-1250</identifier><identifier>EISSN: 1472-1465</identifier><identifier>DOI: 10.1192/bjp.bp.106.032649</identifier><identifier>PMID: 18310578</identifier><identifier>CODEN: BJPYAJ</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Acknowledgment ; Adult ; Amygdala ; Amygdala - physiopathology ; Brain Mapping - methods ; Dopamine ; Emotional behavior ; Emotions ; Facial Expression ; Facial expressions ; Fear ; Fear & phobias ; Female ; Functional magnetic resonance imaging ; Humans ; Information processing ; Magnetic Resonance Imaging - methods ; Male ; Medical imaging ; Mental disorders ; Middle Aged ; Negative symptoms ; Neurosciences ; NMR ; Nuclear magnetic resonance ; Patients ; Pattern recognition ; Pattern Recognition, Visual ; Psychiatry ; Psychoses ; Psychosis ; Psychotic symptoms ; Schizophrenia ; Schizophrenia - physiopathology ; Schizophrenic Psychology ; Sex discrimination ; Social Perception ; Superior temporal gyrus ; Temporal gyrus ; Temporal Lobe - physiopathology ; Trends ; Variance analysis ; Visual processing ; Volunteers</subject><ispartof>British journal of psychiatry, 2008-03, Vol.192 (3), p.191-196</ispartof><rights>Copyright © Royal College of Psychiatrists, 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-5677431af394f97f116bae63a338e74eebc85f3119381abbe8bdaac6d06e80de3</citedby><cites>FETCH-LOGICAL-c537t-5677431af394f97f116bae63a338e74eebc85f3119381abbe8bdaac6d06e80de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2315595862/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2315595862?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,12825,21373,21374,27901,27902,30976,30977,33588,33589,34507,34508,43709,44091,72703,73964,74382</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18310578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Michalopoulou, Panayiota G.</creatorcontrib><creatorcontrib>Surguladze, Simon</creatorcontrib><creatorcontrib>Morley, Lucy A.</creatorcontrib><creatorcontrib>Giampietro, Vincent P.</creatorcontrib><creatorcontrib>Murray, Robin M.</creatorcontrib><creatorcontrib>Shergill, Sukhwinder S.</creatorcontrib><title>Facial fear processing and psychotic symptoms in schizophrenia: functional magnetic resonance imaging study</title><title>British journal of psychiatry</title><addtitle>Br J Psychiatry</addtitle><description>The recognition of negative facial affect is impaired in people with schizophrenia. The neural underpinnings of this deficit and its relationship to the symptoms of psychosis are still unclear.
To examine the association between positive and negative psychotic symptoms and activation within the amygdala and extrastriate visual regions of patients with schizophrenia during fearful and neutral facial expression processing.
Functional magnetic resonance imaging was used to measure neural responses to neutral and fearful facial expressions in 11 patients with schizophrenia and 9 healthy volunteers during an implicit emotional task.
No association between amygdala activation and positive symptoms was found; the activation within the left superior temporal gyrus was negatively associated with the negative symptoms of the patients.
Our results indicate an association between impaired extrastriate visual processing of facial fear and negative symptoms, which may underlie the previously reported difficulties of patients with negative symptoms in the recognition of facial fear.</description><subject>Acknowledgment</subject><subject>Adult</subject><subject>Amygdala</subject><subject>Amygdala - physiopathology</subject><subject>Brain Mapping - methods</subject><subject>Dopamine</subject><subject>Emotional behavior</subject><subject>Emotions</subject><subject>Facial Expression</subject><subject>Facial expressions</subject><subject>Fear</subject><subject>Fear & phobias</subject><subject>Female</subject><subject>Functional magnetic resonance imaging</subject><subject>Humans</subject><subject>Information processing</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Mental disorders</subject><subject>Middle Aged</subject><subject>Negative symptoms</subject><subject>Neurosciences</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Pattern recognition</subject><subject>Pattern Recognition, Visual</subject><subject>Psychiatry</subject><subject>Psychoses</subject><subject>Psychosis</subject><subject>Psychotic symptoms</subject><subject>Schizophrenia</subject><subject>Schizophrenia - physiopathology</subject><subject>Schizophrenic Psychology</subject><subject>Sex discrimination</subject><subject>Social Perception</subject><subject>Superior temporal gyrus</subject><subject>Temporal gyrus</subject><subject>Temporal Lobe - physiopathology</subject><subject>Trends</subject><subject>Variance analysis</subject><subject>Visual processing</subject><subject>Volunteers</subject><issn>0007-1250</issn><issn>1472-1465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><sourceid>ALSLI</sourceid><sourceid>HEHIP</sourceid><sourceid>M2R</sourceid><sourceid>M2S</sourceid><recordid>eNqFkV2L1DAUhoO4uOPqD_BGIoJ3HZPms94ti6sLC3uj1yFJT6cZp2lNWmT89abOwIIge5NwDs95z8eL0BtKtpQ29Ue3n7Zu2lIit4TVkjfP0IZyVVeUS_EcbQghqqK1IJfoZc77EjJeqxfokmpGiVB6g37cWh_sAXdgE57S6CHnEHfYxhZP-ej7cQ4e5-MwzeOQcYg4-z78Hqc-QQz2E-6W6OcwxqIx2F2EFU-QSyJ6wKHkVrk8L-3xFbro7CHD6_N_hb7ffv5287W6f_hyd3N9X3nB1FwJqRRn1Has4V2jOkqlsyCZZUyD4gDOa9GxcgGmqXUOtGut9bIlEjRpgV2hDyfdss_PBfJshpA9HA42wrhko8oZBNXySVComnPGaAHf_wPuxyWVnbOpGRWiEVrWhaInyqcx5wSdmVI5QDoaSsxqmCmGGTeVUJqTYaXm7Vl5cQO0jxVnhwrw7gT0Ydf_CglM8n-NMasgK-86Hjs3toNLod3B43z_b_0Hs3SwAw</recordid><startdate>200803</startdate><enddate>200803</enddate><creator>Michalopoulou, Panayiota G.</creator><creator>Surguladze, Simon</creator><creator>Morley, Lucy A.</creator><creator>Giampietro, Vincent P.</creator><creator>Murray, Robin M.</creator><creator>Shergill, Sukhwinder S.</creator><general>Cambridge University Press</general><general>RCP</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7TK</scope><scope>7XB</scope><scope>88G</scope><scope>88J</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>M2M</scope><scope>M2O</scope><scope>M2R</scope><scope>M2S</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>200803</creationdate><title>Facial fear processing and psychotic symptoms in schizophrenia: functional magnetic resonance imaging study</title><author>Michalopoulou, Panayiota G. ; Surguladze, Simon ; Morley, Lucy A. ; Giampietro, Vincent P. ; Murray, Robin M. ; Shergill, Sukhwinder S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-5677431af394f97f116bae63a338e74eebc85f3119381abbe8bdaac6d06e80de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acknowledgment</topic><topic>Adult</topic><topic>Amygdala</topic><topic>Amygdala - 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Academic</collection><jtitle>British journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Michalopoulou, Panayiota G.</au><au>Surguladze, Simon</au><au>Morley, Lucy A.</au><au>Giampietro, Vincent P.</au><au>Murray, Robin M.</au><au>Shergill, Sukhwinder S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Facial fear processing and psychotic symptoms in schizophrenia: functional magnetic resonance imaging study</atitle><jtitle>British journal of psychiatry</jtitle><addtitle>Br J Psychiatry</addtitle><date>2008-03</date><risdate>2008</risdate><volume>192</volume><issue>3</issue><spage>191</spage><epage>196</epage><pages>191-196</pages><issn>0007-1250</issn><eissn>1472-1465</eissn><coden>BJPYAJ</coden><abstract>The recognition of negative facial affect is impaired in people with schizophrenia. The neural underpinnings of this deficit and its relationship to the symptoms of psychosis are still unclear.
To examine the association between positive and negative psychotic symptoms and activation within the amygdala and extrastriate visual regions of patients with schizophrenia during fearful and neutral facial expression processing.
Functional magnetic resonance imaging was used to measure neural responses to neutral and fearful facial expressions in 11 patients with schizophrenia and 9 healthy volunteers during an implicit emotional task.
No association between amygdala activation and positive symptoms was found; the activation within the left superior temporal gyrus was negatively associated with the negative symptoms of the patients.
Our results indicate an association between impaired extrastriate visual processing of facial fear and negative symptoms, which may underlie the previously reported difficulties of patients with negative symptoms in the recognition of facial fear.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>18310578</pmid><doi>10.1192/bjp.bp.106.032649</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of psychiatry, 2008-03, Vol.192 (3), p.191-196 |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); Social Science Premium Collection; Sociology Collection; Cambridge University Press |
| subjects | Acknowledgment Adult Amygdala Amygdala - physiopathology Brain Mapping - methods Dopamine Emotional behavior Emotions Facial Expression Facial expressions Fear Fear & phobias Female Functional magnetic resonance imaging Humans Information processing Magnetic Resonance Imaging - methods Male Medical imaging Mental disorders Middle Aged Negative symptoms Neurosciences NMR Nuclear magnetic resonance Patients Pattern recognition Pattern Recognition, Visual Psychiatry Psychoses Psychosis Psychotic symptoms Schizophrenia Schizophrenia - physiopathology Schizophrenic Psychology Sex discrimination Social Perception Superior temporal gyrus Temporal gyrus Temporal Lobe - physiopathology Trends Variance analysis Visual processing Volunteers |
| title | Facial fear processing and psychotic symptoms in schizophrenia: functional magnetic resonance imaging study |
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