An efficient enantioselective method for asymmetric Michael addition of nitroalkanes to alpha,beta-unsaturated aldehydes

The addition of nitroalkanes to alpha,beta-unsaturated aldehydes under the catalysis of (S)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine and lithium acetate as additive afforded gamma-nitroaldehydes in good yield and up to 97% ee.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2008-03 (10), p.1232-1234
Main Authors: Wang, Yongcan, Li, Pengfei, Liang, Xinmiao, Zhang, Tony Y, Ye, Jinxing
Format: Article
Language:English
Subjects:
Aldehydes - chemistry
Alkanes - chemistry
Nitrogen Compounds - chemistry
Stereoisomerism
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Summary:The addition of nitroalkanes to alpha,beta-unsaturated aldehydes under the catalysis of (S)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine and lithium acetate as additive afforded gamma-nitroaldehydes in good yield and up to 97% ee.
ISSN:1359-7345
1364-548X
DOI:10.1039/b717000a