Vitamin D fortification of milk products does not resolve hypovitaminosis D in young Finnish men

• Published in: European journal of clinical nutrition 2007-04, Vol.61 (4), p.493-497
• Main Authors: Valimaki, V.V, Loyttyniemi, E, Valimaki, M.J
• Format: Article
• Language: English
• Subjects: 25-hydroxycholecalciferol; 25-Hydroxyvitamin D; Adolescent; Adult; Animals; Biological and medical sciences; Blood; blood sampling; bone density; Bone Density Conservation Agents - administration & dosage; Bone mass; Calciferol; Calcium, Dietary - administration & dosage; Cattle; Chromatography, High Pressure Liquid; Clinical Nutrition; Cohort Studies; Consumption; Correlation analysis; Dietary supplements; Diseases of the osteoarticular system; Epidemiology; Finland; Food, Fortified; fortified foods; High performance liquid chromatography; Humans; Internal Medicine; Liquid chromatography; Longitudinal Studies; Male; Medical sciences; Medicine; Medicine & Public Health; Men; Metabolic Diseases; Milk; Milk products; Nutrition; nutritional adequacy; nutritional status; original-article; Osteoporosis. Osteomalacia. Paget disease; Parathyroid; Parathyroid hormone; Parathyroid Hormone - blood; Public Health; Radioimmunoassay; Supplements; Surveys and Questionnaires; Vitamin D; Vitamin D - administration & dosage; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - diet therapy; Vitamin D Deficiency - epidemiology; vitamin deficiencies; Vitamin deficiency; young adults
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/sj.ejcn.1602550

Objective: To study if vitamin D fortification of milk products started in February 2003 has improved vitamin D status of young Finnish men, which has been poor before. Design: A longitudinal study of one cohort. Setting: Helsinki University Central Hospital. Subjects: Sixty-five healthy men, studied for the first time in January 2001, were re-examined in January 2004. They were aged 18-21 years in 2001. Methods: Blood was sampled for determination of serum 25-hydroxyvitamin D (25-OHD) and intact parathyroid hormone (iPTH). 25-OHD was measured by both radioimmunoassay (RIA) and high-pressure liquid chromatography (HPLC). Consumption of milk, sour milk and fish and use of vitamin D supplements were assessed using a questionnaire. Results: In January 2004, vitamin D fortification had raised serum 25-OHD level, with the mean of individual percent changes being 20.4% measured with RIA (P=0.0015). The correlation between the RIA and HPLC methods was high (r=0.85). Nineteen men (29.2%) had vitamin D deficiency (25-OHD