Atopic dermatitis: insights from linkage overlap and disease co-morbidity

Atopic dermatitis (AD) is a strongly heritable, chronic relapsing dermatosis that frequently co-occurs with other atopic phenotypes including asthma and allergic rhinitis (the so-called atopic triad disorders). However, despite high levels of co-morbidity, relatively low levels of genomic co-inciden...

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Bibliographic Details
Published in:Expert reviews in molecular medicine 2007-03, Vol.9 (9), p.1-13
Main Authors: Willis-Owen, Saffron A.G., Morar, Nilesh, Willis-Owen, Charles A.
Format: Article
Language:English
Subjects:
Asthma - epidemiology
Comorbidity
Dermatitis, Atopic - epidemiology
Dermatitis, Atopic - genetics
Genetic Linkage
Humans
Psoriasis - epidemiology
Rhinitis - epidemiology
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Summary:Atopic dermatitis (AD) is a strongly heritable, chronic relapsing dermatosis that frequently co-occurs with other atopic phenotypes including asthma and allergic rhinitis (the so-called atopic triad disorders). However, despite high levels of co-morbidity, relatively low levels of genomic co-incidence have been observed between atopic triad disorders. Conversely, current mapping data have revealed a striking pattern of co-localisation between AD disease loci and those mapped using another chronic dermatological disease – psoriasis. In this review, we examine the evidence for co-localisation between AD and a range of atopic, infectious, inflammatory and autoimmune diseases, and consider the implications of these data for the AD disease concept and future research in the field.
ISSN:1462-3994
1462-3994
DOI:10.1017/S1462399407000282