Clinical results of intraoperative radiation therapy for patients with locally recurrent and advanced tumors having colorectal involvement

Abstract Background Intraoperative radiation therapy (IORT) may be useful in the treatment of patients who have a locally advanced primary and recurrent abdominopelvic neoplasm with colorectal involvement. Methods A retrospective review of colorectal cancer patients treated since 1999 with IORT usin...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of surgery 2008-03, Vol.195 (3), p.405-409
Main Authors: Williams, Christina P., M.D, Reynolds, Harry L., M.D, Delaney, Conor P., M.D., Ph.D, Champagne, Brad, M.D, Obias, Vincent, M.D, Joh, Yong-Geul, M.D, Merlino, Jim, M.D, Kinsella, Timothy J., M.D
Format: Article
Language:English
Subjects:
Abdomen
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Chemotherapy
Colectomy
Colorectal cancer
Colorectal Neoplasms - pathology
Colorectal Neoplasms - radiotherapy
Colorectal Neoplasms - surgery
Female
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Humans
Intraoperative
Intraoperative Period
Male
Medical sciences
Middle Aged
Mortality
Neoplasm Recurrence, Local - radiotherapy
Radiation
Radiotherapy, Adjuvant
Recurrence
Retrospective Studies
Sacrectomy
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Surgery
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background Intraoperative radiation therapy (IORT) may be useful in the treatment of patients who have a locally advanced primary and recurrent abdominopelvic neoplasm with colorectal involvement. Methods A retrospective review of colorectal cancer patients treated since 1999 with IORT using the Mobetron device. Results Forty patients underwent colectomy or proctectomy with IORT. All patients had evidence of local extension to contiguous structures and based on preoperative staging were deemed by the operating surgeon as being likely to have incomplete resection. IORT was selected as an alternative to sacrectomy or exenteration for an expected close margin in 10 patients. Mean survival was 35 ± 26 months, and 1 patient had local recurrence. Conclusions The introduction of IORT has allowed a selective treatment approach to locally advanced primary and recurrent neoplasms, which traditionally would have been deemed unresectable. Using IORT, extended resections may be avoided in selected high-risk patients with low risk of local recurrence and minimal morbidity.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2007.12.002