Insulin sensitivity in Type 1 diabetic children and adolescents

• Published in: Diabetic medicine 2008-03, Vol.25 (3), p.282-288
• Main Authors: Szadkowska, A., Pietrzak, I., Mianowska, B., Bodalska-Lipińska, J., Keenan, H. A., Toporowska-Kowalska, E., Młynarski, W., Bodalski, J.
• Format: Article
• Language: English
• Subjects: Adipose Tissue - pathology; Adolescent; adolescents; Biological and medical sciences; Blood Glucose - metabolism; Child; children; diabetes; Diabetes Mellitus, Type 1 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Humans; Insulin Resistance - physiology; insulin sensitivity; Lipids - blood; Male; Medical sciences; obesity; Obesity - complications; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology
• ISSN: 0742-3071; 1464-5491
• DOI: 10.1111/j.1464-5491.2007.02357.x

Aim  To estimate insulin sensitivity in Type 1 diabetic children and adolescents, and assess the relationship between insulin sensitivity and clinical markers of adiposity and parameters of the metabolic syndrome. Methods  A total of 202 patients aged 8–18 years with Type 1 diabetes and disease duration 1.5–15 years participated. Insulin sensitivity was estimated by glucose uptake during an euglycaemic–hyperinsulinaemic clamp and was calculated as the average amount of glucose (Mlbm = mg/kglbm/min) required to maintain euglycaemia. Blood pressure, glycated haemoglobin (HbA1c) and lipid concentrations were measured. Results  The Mlbm value ranged from 4.14 to 25.25 mg/kglbm/min (mean 9.81 ± 3.34 mg/kglbm/min). There was a significant relationship between M value and patients’ age (r = –0.38, P