Factors Influencing Left Ventricular Structure and Stress-Corrected Systolic Function in Men and Women With Asymptomatic Aortic Valve Stenosis (a SEAS Substudy)

• Published in: The American journal of cardiology 2008-02, Vol.101 (4), p.510-515
• Main Authors: Cramariuc, Dana, MD, Rieck, Åshild E, Staal, Eva M., MD, PhD, Wachtell, Kristian, MD, PhD, Eriksen, Erlend, MD, Rossebø, Anne B., MD, Gerdts, Eva, MD, PhD
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Aortic Valve Stenosis - epidemiology; Biological and medical sciences; Cardiology. Vascular system; Cardiovascular; Echocardiography, Doppler; Endocardial and cardiac valvular diseases; Female; Gender differences; Heart; Heart Rate; Heart Ventricles - diagnostic imaging; Humans; Hypertension; Hypertension - epidemiology; Hypertrophy, Left Ventricular - diagnostic imaging; Male; Medical sciences; Middle Aged; Multivariate Analysis; Myocardial Contraction; Older people; Prospective Studies; Regression analysis; Severity of Illness Index; Sex Factors; Studies; Systole; Ultrasonic imaging
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2007.09.100

To identify determinants of left ventricular (LV) structure and stress-corrected systolic function in men and women with asymptomatic aortic stenosis (AS), Doppler echocardiography was performed at baseline in 1,046 men and 674 women 28 to 86 years of age (mean 67 ± 10) recruited in the Simvastatin Ezetimibe in Aortic Stenosis (SEAS) study evaluating placebo-controlled combined simvastatin and ezetimibe treatment in AS. LV hypertrophy was less prevalent in women despite older age, higher systolic blood pressure, and smaller aortic valve area/body surface area (all p values