The Association Between Vitamin D and Inflammation with the 6-Minute Walk and Frailty in Patients with Heart Failure

OBJECTIVES: To identify relationships between anabolic hormones, inflammatory markers, and physical function. DESIGN: Cross‐sectional. SETTING: Outpatient university heart failure program in Connecticut. PARTICIPANTS: Sixty patients with an ejection fraction of 40% or less. MEASUREMENTS: The 6‐minut...

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Bibliographic Details
Published in:Journal of the American Geriatrics Society (JAGS) 2008-03, Vol.56 (3), p.454-461
Main Authors: Boxer, Rebecca S., Dauser, Deborah A., Walsh, Stephen J., Hager, W. David, Kenny, Anne M.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
C-Reactive Protein - metabolism
Cardiology
Cardiology. Vascular system
Cross-Sectional Studies
Exercise Test
Exercise Tolerance - physiology
Female
Frail Elderly
Frailty
General aspects
Health Status
Heart
Heart failure
Heart Failure - blood
Heart Failure - physiopathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Hormones
Humans
inflammation
Interleukin-6 - blood
Male
Medical sciences
Miscellaneous
Older people
Public health. Hygiene
Public health. Hygiene-occupational medicine
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
walk
Walking
Walking - physiology
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Summary:OBJECTIVES: To identify relationships between anabolic hormones, inflammatory markers, and physical function. DESIGN: Cross‐sectional. SETTING: Outpatient university heart failure program in Connecticut. PARTICIPANTS: Sixty patients with an ejection fraction of 40% or less. MEASUREMENTS: The 6‐minute walk distance and frailty phenotype were measured. The relationship between physical measures of hormones and inflammatory mediators were examined. Linear and ordinal logistic regression analyses were performed for the physical measures. RESULTS: Forty‐three men (mean age 77 ± 9) and 17 women (mean age 78 ± 12) participated. Longer 6‐minute walk distance was correlated with higher 25‐hydroxyvitamin D (25OHD) level, and a shorter walk was correlated with higher cortisol: dehydroepiandrosterone sulphate (DHEAS) ratio, high‐sensitivity C‐reactive protein (hsCRP), interleukin‐6 (IL6), and intact parathyroid hormone (PTH) (all P
ISSN:0002-8614
1532-5415
DOI:10.1111/j.1532-5415.2007.01601.x