Magnetic targeting after femoral artery administration and biocompatibility assessment of superparamagnetic iron oxide nanoparticles

Ferrofluids are attractive candidates for magnetic targeting system because of their fluidity and magnetism. The magnetic nanoparticles in ferrofluids should have combined properties of superparamagnetic behavior, target localization, and biocompatibility. The magnetic targeting and biocompatibility...

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Published in:Journal of biomedical materials research. Part A 2008-03, Vol.84A (3), p.598-606
Main Authors: Ma, Hui-Li, Qi, Xian-Rong, Ding, Wu-Xiao, Maitani, Yoshie, Nagai, Tsuneji
Format: Article
Language:English
Subjects:
alginate
Alginates
Animals
biocompatibility
Biocompatible Materials - administration & dosage
Cell Line
Drug Delivery Systems - methods
Femoral Artery
Ferric Compounds - administration & dosage
Glucuronic Acid
Hexuronic Acids
Injections, Intra-Arterial
localization ratio
magnetic targeting
Magnetics
Male
Mice
Nanoparticles - administration & dosage
Rabbits
Rats
Rats, Sprague-Dawley
Staining and Labeling
superparamagnetic iron oxide nanoparticles (SPION)
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Summary:Ferrofluids are attractive candidates for magnetic targeting system because of their fluidity and magnetism. The magnetic nanoparticles in ferrofluids should have combined properties of superparamagnetic behavior, target localization, and biocompatibility. The magnetic targeting and biocompatibility of superparamagnetic iron oxide nanoparticles stabilized by alginate (SPION‐alginate) was investigated in vitro and in vivo. The localization of SPION‐alginate by an external magnetic field in vitro was quantitatively evaluated by determining the iron content, and the results revealed that the localization ratio of SPION‐alginate was 56%. Magnetic targeting of the SPION‐alginate after femoral artery administration with the magnetic field in rats was quantitatively investigated by iron content and qualitatively confirmed by histological evaluation and magnetic resonance imaging. The ratio of iron content between the target site and the nontarget site were 8.88 at 0.5 h and 7.50 at 2 h, respectively. The viability of RAW264.7 cells and L929 cells was apparently unaltered upon exposure to SPION‐alginate. The incubation with erythrocytes indicated that the SPION‐alginate did not induce erythrocytes hemolysis and aggregation. In conclusions, the SPION‐alginate had magnetic targeting with an external magnetic field and did not be detained at the injection site without the magnetic field. The SPION‐alginate was generally considered to be biocompatible in cytotoxicity and hemolysis aspects. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.31346