Ultra-fast and accurate assessment of cardiac function in rats using accelerated MRI at 9.4 Tesla

MRI can accurately and reproducibly assess cardiac function in rodents but requires relatively long imaging times. Therefore, parallel imaging techniques using a 4‐element RF‐coil array and MR sequences for cardiac MRI in rats were implemented at ultra‐high magnetic fields (9.4 Tesla [T]). The hypot...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2008-03, Vol.59 (3), p.636-641
Main Authors: Schneider, Jürgen E., Lanz, Titus, Barnes, Hannah, Medway, Debra, Stork, Lee-Anne, Lygate, Craig A., Smart, Sean, Griswold, Mark A., Neubauer, Stefan
Format: Article
Language:English
Subjects:
Animals
cardiac function
Equipment Design
Female
Heart - physiology
heart failure
Image Processing, Computer-Assisted
Magnetic Resonance Imaging, Cine - instrumentation
Magnetic Resonance Imaging, Cine - methods
MRI
rat model
Rats
Rats, Wistar
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Summary:MRI can accurately and reproducibly assess cardiac function in rodents but requires relatively long imaging times. Therefore, parallel imaging techniques using a 4‐element RF‐coil array and MR sequences for cardiac MRI in rats were implemented at ultra‐high magnetic fields (9.4 Tesla [T]). The hypothesis that these developments would result in a major reduction in imaging time without loss of accuracy was tested on female Wistar rats under isoflurane anesthesia. High‐resolution, contiguous short‐axis slices (thickness 1.5 mm) were acquired covering the entire heart. Two interleaved data sets (i) with the volume coil (eight averages) and (ii) with the four‐element coil array (one average) were obtained. In addition, two‐, three‐, and fourfold accelerated data sets were generated through postprocessing of the coil array data, followed by a TGRAPPA reconstruction, resulting in five data sets per rat (in‐plane voxel size 100 × 100 μm). Using a single blinded operator, excellent agreement was obtained between volume coil (acquisition time: 88 min) and the fourfold accelerated (
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.21491