Evolution of gene sequence and gene expression are not correlated in yeast

We show that, in yeast, the divergence rate of gene expression is not correlated with that of its associated coding sequence. Gene essentiality influences both modes of evolution, but other properties related to protein structure or promoter composition are only correlated with coding-sequence diver...

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Bibliographic Details
Published in:Trends in genetics 2008-03, Vol.24 (3), p.109-113
Main Authors: Tirosh, Itay, Barkai, Naama
Format: Article
Language:English
Subjects:
Base Sequence
Biological and medical sciences
Biological evolution
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Fungal - genetics
Genetics of eukaryotes. Biological and molecular evolution
Medical Education
Saccharomyces cerevisiae - genetics
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Summary:We show that, in yeast, the divergence rate of gene expression is not correlated with that of its associated coding sequence. Gene essentiality influences both modes of evolution, but other properties related to protein structure or promoter composition are only correlated with coding-sequence divergence or gene expression divergence, respectively. Based on these findings, we discuss the possibilities of neutral evolution of gene expression and of different modes of evolution in unicellular versus multicellular organisms.
ISSN:0168-9525
DOI:10.1016/j.tig.2007.12.004