Atherosclerotic and thrombophilic risk factors in patients with recurrent central retinal vein occlusion

Atherosclerotic and thrombophilic risk factors may be causes of central retinal vein occlusion (CRVO). The aim of this study was to evaluate the prevalence of the aforesaid risk factors in patients with recurrent CRVOs and patients with a single episode of CRVO. Seventeen patients with recurrent CRV...

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Bibliographic Details
Published in:European journal of ophthalmology 2008-03, Vol.18 (2), p.233-238
Main Authors: Sodi, A, Giambene, B, Marcucci, R, Sofi, F, Bolli, P, Abbate, R, Prisco, D, Menchini, U
Format: Article
Language:English
Subjects:
Aged
Atherosclerosis - complications
Atherosclerosis - diagnosis
Biomarkers - analysis
Chromatography, High Pressure Liquid
Dyslipidemias - complications
Dyslipidemias - diagnosis
Enzyme-Linked Immunosorbent Assay
Female
Humans
Hyperhomocysteinemia - complications
Hyperhomocysteinemia - diagnosis
Male
Prevalence
Radioimmunoassay
Recurrence
Retinal Vein Occlusion - etiology
Risk Factors
Thrombophilia - complications
Thrombophilia - diagnosis
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Summary:Atherosclerotic and thrombophilic risk factors may be causes of central retinal vein occlusion (CRVO). The aim of this study was to evaluate the prevalence of the aforesaid risk factors in patients with recurrent CRVOs and patients with a single episode of CRVO. Seventeen patients with recurrent CRVO and 30 with a single episode of CRVO were enrolled. The atherosclerotic risk factors investigated were hypertension, diabetes, smoking, and dyslipidemia. Specific laboratory tests for the following thrombophilic markers were performed: homocystinemia (Hcy), lipoprotein (a), factor VIII, factor II G20210A and factor V G1691A polymorphisms, lupus anticoagulant, anticardiolipin antibodies, plasminogen activator inhibitor-1, and deficit of vitamins B6, B12, and folic acid. A multivariate analysis, adjusted for age, gender, traditional and thrombophilic risk factors, was performed. Statistical significance was set at p
ISSN:1120-6721
1724-6016
DOI:10.1177/112067210801800211