Steroid-responsive nephrotic syndrome in a child with juvenile idiopathic arthritis

Renal disease is rare in children with juvenile idiopathic arthritis, although a number of associated nephropathies have been described, including mesangial glomerulonephritis. We report the presence of mesangial glomerulonephritis, revealed by a nephrotic syndrome, in a paediatric patient with juve...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2008-04, Vol.23 (4), p.651-654
Main Authors: Bandin, Flavio, Merhenberger, Marion, Modesto, Anne, Brochard, Karine, Decramer, Stéphane
Format: Article
Language:English
Subjects:
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Arthritis, Juvenile - complications
Arthritis, Juvenile - drug therapy
Arthritis, Juvenile - pathology
Brief Report
Drug Therapy, Combination
Female
Glomerular Mesangium - metabolism
Glomerular Mesangium - pathology
Glucocorticoids - therapeutic use
Humans
Infant
Kidney - metabolism
Kidney - pathology
Medicine & Public Health
Microscopy, Fluorescence
Nephrology
Nephrotic Syndrome - complications
Nephrotic Syndrome - drug therapy
Nephrotic Syndrome - pathology
Pediatrics
Prednisone - therapeutic use
Remission Induction
Urology
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Summary:Renal disease is rare in children with juvenile idiopathic arthritis, although a number of associated nephropathies have been described, including mesangial glomerulonephritis. We report the presence of mesangial glomerulonephritis, revealed by a nephrotic syndrome, in a paediatric patient with juvenile idiopathic arthritis. Short-term steroid treatment induced a rapid remission of the nephrotic syndrome, but the presence of anti-nuclear antibodies, 1:320 in a homogeneous pattern, irregular deposits of C1q in a renal biopsy, and a mother with episodes of cutaneous lupus suggested an uncertain renal evolution for this infant.
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-007-0678-9