Vaccination with a T-cell-priming Gag peptide of caprine arthritis encephalitis virus enhances virus replication transiently in vivo

CD4(+) T cells are involved in several immune response pathways used to control viral infections. In this study, a group of genetically defined goats was immunized with a synthetic peptide known to encompass an immunodominant helper T-cell epitope of caprine arthritis encephalitis virus (CAEV). Fift...

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Bibliographic Details
Published in:Journal of general virology 2007-05, Vol.88 (5), p.1589-1593
Main Authors: Nenci, C, Zahno, M.L, Vogt, H.R, Obexer-Ruff, G, Doherr, M.G, Zanoni, R, Peterhans, E, Bertoni, G
Format: Article
Language:English
Subjects:
Animals
Arthritis - veterinary
Arthritis - virology
Arthritis-Encephalitis Virus, Caprine - genetics
Arthritis-Encephalitis Virus, Caprine - immunology
Biological and medical sciences
Caprine arthritis encephalitis virus
epitopes
Fundamental and applied biological sciences. Psychology
Gag peptide
gene expression
Gene Products, gag - immunology
Goat Diseases - virology
Goats
granulocyte-macrophage colony-stimulating factor
helper cells
interferons
interleukin-4
leukocytes
messenger RNA
Microbiology
Miscellaneous
Peptides - immunology
peripheral blood mononuclear cell
Pneumonia - veterinary
Pneumonia - virology
RNA, Messenger - genetics
RNA, Viral - genetics
T-lymphocytes
T-Lymphocytes - immunology
T-Lymphocytes - virology
vaccination
viral antigens
viral proteins
Viral Vaccines
Virology
virus replication
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Summary:CD4(+) T cells are involved in several immune response pathways used to control viral infections. In this study, a group of genetically defined goats was immunized with a synthetic peptide known to encompass an immunodominant helper T-cell epitope of caprine arthritis encephalitis virus (CAEV). Fifty-five days after challenge with the molecularly cloned CAEV strain CO, the vaccinated animals had a higher proviral load than the controls. The measurement of gamma interferon and interleukin-4 gene expression showed that these cytokines were reliable markers of an ongoing immune response but their balance did not account for more or less efficient control of CAEV replication. In contrast, granulocyte-macrophage colony-stimulating factor appeared to be a key cytokine that might support virus replication in the early phase of infection. The observation of a potential T-cell-mediated enhancement of virus replication supports other recent findings showing that lentivirus-specific T cells can be detrimental to the host, suggesting caution in designing vaccine candidates.
ISSN:0022-1317
1465-2099
DOI:10.1099/vir.0.82800-0