Chemotherapy of leishmaniasis Part VI: Synthesis and bioevaluation of some novel terpenyl S, N- and N, N-acetals

• Published in: European journal of medicinal chemistry 2007-04, Vol.42 (4), p.511-516
• Main Authors: Suryawanshi, S.N., Pandey, Susmita, Rashmirathi, Bhatt, B.A., Gupta, Suman
• Format: Article
• Language: English
• Subjects: Acetals - chemical synthesis; Acetals - therapeutic use; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antileishmanial activity; Antiparasitic agents; Antiprotozoal Agents - chemical synthesis; Antiprotozoal Agents - therapeutic use; Biological and medical sciences; Cricetinae; Disease Models, Animal; Ionones; Leishmania donovani - drug effects; Leishmaniasis - drug therapy; Male; Medical sciences; Molecular Structure; Oxoketene S, N- and N, N-acetals; Parasitic Sensitivity Tests; Pharmacology. Drug treatments; Terpenes - chemical synthesis; Terpenes - therapeutic use
• ISSN: 0223-5234; 1768-3254
• DOI: 10.1016/j.ejmech.2006.09.016

Some novel terpene based oxoketene S, N-acetals 2( a– g) and N, N-acetals 3( a– c) have been synthesized from oxoketene dithioacetal 1. The compounds were screened for their in vivo antileishmanial activity. Some of the compounds showed 50–70% inhibition in the hamster model. [Display omitted] Some novel terpene based oxoketene S, N-acetals 2( a– g) and N, N-acetals 3( a– c) have been synthesized from oxoketene dithioacetal 1 and the compounds were screened for their in vivo antileishmanial activity. Some of the compounds showed 50–70% inhibition in the hamster model.