Vaccination of Porcine Circovirus type 2 (PCV2)-infected Sows against Porcine Parvovirus (PPV) and Erysipelas: Effect on Post-weaning Multisystemic Wasting Syndrome (PMWS) and on PCV2 Genome Load in the Offspring

• Published in: Journal of comparative pathology 2007-02, Vol.136 (2), p.133-144
• Main Authors: Rose, N., Blanchard, P., Cariolet, R., Grasland, B., Amenna, N., Oger, A., Durand, B., Balasch, M., Jestin, A., Madec, F.
• Format: Article
• Language: English
• Subjects: Animals; Circovirus - genetics; Circovirus - immunology; disease transmission; DNA, Viral - analysis; erysipelas; Female; In Situ Hybridization - veterinary; Parvoviridae Infections - pathology; Parvoviridae Infections - prevention & control; Parvoviridae Infections - veterinary; Parvoviridae Infections - virology; Parvovirus, Porcine - genetics; Parvovirus, Porcine - immunology; passive immunity; pig; PMWS; Porcine circovirus; Porcine parvovirus; postweaning multisystemic wasting syndrome; Pregnancy; Pregnancy Outcome - veterinary; progeny; Reverse Transcriptase Polymerase Chain Reaction; sows; Specific Pathogen-Free Organisms; Swine; swine diseases; Swine Diseases - immunology; Swine Diseases - pathology; Swine Diseases - virology; swine erysipelas; Swine Erysipelas - pathology; Swine Erysipelas - prevention & control; Swine Erysipelas - virology; vaccination; Vaccination - veterinary; vaccines; viral diseases of animals and humans; viral infection; virus replication; Wasting Syndrome - pathology; Wasting Syndrome - prevention & control; Wasting Syndrome - veterinary; Wasting Syndrome - virology
• ISSN: 0021-9975; 1532-3129
• DOI: 10.1016/j.jcpa.2007.01.006

The effect of different Parvovirus+ Erysipelas vaccination schemes in PCV2-infected sows on PMWS outcome in the offspring was investigated under experimental conditions. Six PCV2-free sows were first infected oro-nasally with PCV2 two months before insemination (D0; “Day 0”) and then by the intra-uterine route at insemination (D62). On D21 and D42, vaccinated sows received either the two commercial monovalent vaccines, A1(PPV) and A2(Erysipelas), or the bivalent vaccine B (PPV+Erysipelas). In addition, three SPF sows (foster-sows) were synchronized for farrowing dates to enable them to foster piglets born to infected sows and removed at birth before colostrum intake. A significantly higher proportion of mummified fetuses was obtained from PCV2-infected non-vaccinated sows than from vaccinated sows. Acute myocarditis lesions were found in their piglets, together with a high PCV2 genome load. The latter was significantly higher than in those born to PCV2-infected vaccinated sows. Sentinel PCV2-negative piglets, born to SPF foster-sows, seroconverted at almost the same time as piglets without PCV2 passive immunity and born to infected sows. Sixteen of the 84 liveborn piglets born to infected sows and foster-sows were affected by a syndrome possibly related to PMWS, as judged by clinical signs and histological lesions. Most were born to PCV2-infected non-vaccinated sows and 12/16 did not receive PCV2 passive immunity. The probability of PCV2 infection and the number of PCV2 genome copies per gram of tissue were significantly increased in piglets that did not receive PCV2 passive immunity.