Production and functions of IL-17 in microglia

Abstract Interleukin (IL)-17-producing helper T cells may play a pivotal role in the pathogenesis of multiple sclerosis. Here, we examined the effects of IL-17 on microglia, which are known to be critically involved in multiple sclerosis. Treatment with IL-17 upregulated the microglial production of...

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Bibliographic Details
Published in:Journal of neuroimmunology 2008-02, Vol.194 (1), p.54-61
Main Authors: Kawanokuchi, Jun, Shimizu, Kouki, Nitta, Atsumi, Yamada, Kiyofumi, Mizuno, Tetsuya, Takeuchi, Hideyuki, Suzumura, Akio
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Autocrine Communication
Brain-Derived Neurotrophic Factor - biosynthesis
Brain-Derived Neurotrophic Factor - genetics
Cells, Cultured - drug effects
Cells, Cultured - metabolism
Chemokine CXCL2 - biosynthesis
Chemokine CXCL2 - genetics
Cytokine
EAE
Gene Expression Regulation - drug effects
Glial Cell Line-Derived Neurotrophic Factor - biosynthesis
Glial Cell Line-Derived Neurotrophic Factor - genetics
Humans
IL-17
Interleukin-17 - biosynthesis
Interleukin-17 - pharmacology
Interleukin-17 - physiology
Interleukin-1beta - biosynthesis
Interleukin-1beta - genetics
Interleukin-23 - biosynthesis
Interleukin-23 - genetics
Interleukin-6 - biosynthesis
Interleukin-6 - genetics
Mice
Microglia
Microglia - drug effects
Microglia - metabolism
Multiple Sclerosis - metabolism
Neurology
Nitric Oxide - biosynthesis
Receptors, Interleukin-17 - biosynthesis
Receptors, Interleukin-17 - genetics
Recombinant Proteins - pharmacology
RNA, Messenger - biosynthesis
Tumor Necrosis Factor-alpha - biosynthesis
Tumor Necrosis Factor-alpha - genetics
Up-Regulation - drug effects
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Summary:Abstract Interleukin (IL)-17-producing helper T cells may play a pivotal role in the pathogenesis of multiple sclerosis. Here, we examined the effects of IL-17 on microglia, which are known to be critically involved in multiple sclerosis. Treatment with IL-17 upregulated the microglial production of IL-6, macrophage inflammatory protein-2, nitric oxide, adhesion molecules, and neurotrophic factors. We also found that IL-17 was produced by microglia in response to IL-23 or IL-1β. Because microglia produce IL-1β and IL-23, these cytokines may act in an autocrine manner to induce IL-17 expression in microglia, and thereby contribute to autoimmune diseases, such as MS, in the central nervous system.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2007.11.006