Lessons learned from an animal model of Kawasaki disease

Kawasaki disease is the most common cause of multisystem vasculitis in childhood. Kawasaki disease has been reported throughout the world and affects children of all ethnicity. Coronary artery damage from Kawasaki disease is the leading cause of acquired heart disease in children in the developed wo...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2007, Vol.25 (1), p.S69-S71
Main Author: YEUNG, R. S. M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Child
Coronary Aneurysm - diagnosis
Coronary Aneurysm - prevention & control
Disease Models, Animal
Humans
Immunoglobulins, Intravenous - therapeutic use
Medical sciences
Mice
Mice, Inbred Strains
Mucocutaneous Lymph Node Syndrome - drug therapy
Mucocutaneous Lymph Node Syndrome - etiology
Mucocutaneous Lymph Node Syndrome - pathology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Summary:Kawasaki disease is the most common cause of multisystem vasculitis in childhood. Kawasaki disease has been reported throughout the world and affects children of all ethnicity. Coronary artery damage from Kawasaki disease is the leading cause of acquired heart disease in children in the developed world. Diagnostic tests and prognostic markers are lacking, and questions remain unanswered in our understanding of the etiopathogenesis of the disease, thus limiting our ability to improve therapy and coronary outcome. In this article I will review advances made in an animal model of disease, which has helped advance our understanding of the etiology and pathogenesis of this fascinating clinical syndrome.
ISSN:0392-856X
1593-098X