Polarizability of G4-DNA Observed by Electrostatic Force Microscopy Measurements

G4-DNA, a quadruple helical motif of stacked guanine tetrads, is stiffer and more resistant to surface forces than double-stranded DNA (dsDNA), yet it enables self-assembly. Therefore, it is more likely to enable charge transport upon deposition on hard supports. We report clear evidence of polariza...

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Bibliographic Details
Published in:Nano letters 2007-04, Vol.7 (4), p.981-986
Main Authors: Cohen, Hezy, Sapir, Tomer, Borovok, Natalia, Molotsky, Tatiana, Di Felice, Rosa, Kotlyar, Alexander B, Porath, Danny
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Anisotropy
Biological and medical sciences
Cross-disciplinary physics: materials science
rheology
DNA - chemistry
Electric Conductivity
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
G-Quadruplexes
General aspects, investigation methods
Materials science
Methods of nanofabrication
Microscopy, Atomic Force - methods
Molecular Conformation
Nanostructures - chemistry
Nucleic acids
Physics
Self-assembly
Static Electricity
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Summary:G4-DNA, a quadruple helical motif of stacked guanine tetrads, is stiffer and more resistant to surface forces than double-stranded DNA (dsDNA), yet it enables self-assembly. Therefore, it is more likely to enable charge transport upon deposition on hard supports. We report clear evidence of polarizability of long G4-DNA molecules measured by electrostatic force microscopy, while coadsorbed dsDNA molecules on mica are electrically silent. This is another sign that G4-DNA is potentially better than dsDNA as a conducting molecular wire.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl070013b