The function of serotonin within the liver

Serotonin or 5-hydroxytryptamine (5-HT) is known to regulate several key aspects of liver biology and these functions include hepatic blood flow, innervation and wound healing. Given the importance of these functions it is surprising that relatively little time has been dedicated to studying the pre...

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Bibliographic Details
Published in:Journal of hepatology 2008-04, Vol.48 (4), p.666-675
Main Authors: Ruddell, Richard G, Mann, Derek A, Ramm, Grant A
Format: Article
Language:English
Subjects:
5-Hydroxytryptamine/serotonin
Animals
Biological and medical sciences
Gastroenterology and Hepatology
Gastroenterology. Liver. Pancreas. Abdomen
Haemodynamics
Humans
Innervation
Liver
Liver - innervation
Liver - physiology
Liver Circulation - physiology
Medical sciences
Serotonin - physiology
Wound healing
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Summary:Serotonin or 5-hydroxytryptamine (5-HT) is known to regulate several key aspects of liver biology and these functions include hepatic blood flow, innervation and wound healing. Given the importance of these functions it is surprising that relatively little time has been dedicated to studying the precise function and mechanisms of serotonin within the liver. Here we describe what is known about serotonin and the liver and those receptor types that mediate the observed effects with an aim to stimulating new interest in the field of serotonin and liver biology.
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2008.01.006