Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: Proof of concept

Antioxidant-rich diets are associated with reduced asthma prevalence. However, direct evidence that altering intake of antioxidant-rich foods affects asthma is lacking. The objective was to investigate changes in asthma and airway inflammation resulting from a low antioxidant diet and subsequent use...

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Bibliographic Details
Published in:Free radical research 2008, Vol.42 (1), p.94-102
Main Authors: Wood, Lisa G., Garg, Manohar L., Powell, Heather, Gibson, Peter G.
Format: Article
Language:English
Subjects:
Anti-Asthmatic Agents - administration & dosage
Anti-Asthmatic Agents - therapeutic use
Antioxidants - administration & dosage
Antioxidants - therapeutic use
asthma
Asthma - drug therapy
Asthma - physiopathology
Beverages
carotenoids
Carotenoids - administration & dosage
Carotenoids - blood
Carotenoids - therapeutic use
Cross-Over Studies
diet
Dietary Supplements
Female
Forced Expiratory Volume - drug effects
Fruit
Humans
Inflammation - drug therapy
Inflammation - physiopathology
Leukocyte Elastase - metabolism
Lycopene
Lycopersicon esculentum
Male
Middle Aged
neutrophilic inflammation
Neutrophils - drug effects
Neutrophils - enzymology
Plant Extracts - therapeutic use
Severity of Illness Index
Sputum - cytology
Treatment Outcome
Vital Capacity - drug effects
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Summary:Antioxidant-rich diets are associated with reduced asthma prevalence. However, direct evidence that altering intake of antioxidant-rich foods affects asthma is lacking. The objective was to investigate changes in asthma and airway inflammation resulting from a low antioxidant diet and subsequent use of lycopene-rich treatments. Asthmatic adults (n=32) consumed a low antioxidant diet for 10 days, then commenced a randomized, cross-over trial involving 3×7 day treatment arms (placebo, tomato extract (45 mg lycopene/day) and tomato juice (45 mg lycopene/day)). With consumption of a low antioxidant diet, plasma carotenoid concentrations decreased, Asthma Control Score worsened, %FEV1 and %FVC decreased and %sputum neutrophils increased. Treatment with both tomato juice and extract reduced airway neutrophil influx. Treatment with tomato extract also reduced sputum neutrophil elastase activity. In conclusion, dietary antioxidant consumption modifies clinical asthma outcomes. Changing dietary antioxidant intake may be contributing to rising asthma prevalence. Lycopene-rich supplements should be further investigated as a therapeutic intervention.
ISSN:1071-5762
1029-2470
DOI:10.1080/10715760701767307