BCL-2, TP53 and BAX protein expression in superficial urothelial bladder carcinoma

Abstract Whether TP53, BCL-2 and BAX expressions add independent prognostic information in patients with Ta/T1bladder urothelial carcinoma remains unclear. TP53 overexpression correlated with high tumor grade ( p = 0.004), WHO grading categories (0.045), BAX expression ( p = 0.043) and pathologic st...

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Bibliographic Details
Published in:Cancer letters 2007-06, Vol.250 (2), p.292-299
Main Authors: Gonzalez-Campora, Ricardo, Davalos-Casanova, Guillermo, Beato-Moreno, Antonio, Garcia-Escudero, Antonio, Pareja Megia, Maria Jesus, Montironi, Rodolfo, Lopez-Beltran, Antonio
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Apoptosis
BAX
BCL-2
bcl-2-Associated X Protein - metabolism
Bladder
Bladder cancer
Confidence intervals
Female
Hematology, Oncology and Palliative Medicine
Humans
Immunohistochemistry
Male
Medical prognosis
Middle Aged
Mortality
Multivariate analysis
Proto-Oncogene Proteins c-bcl-2 - metabolism
Statistical analysis
Survival Analysis
TP53
Tumor Suppressor Protein p53 - metabolism
Tumors
Urinary Bladder Neoplasms - metabolism
Variables
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Summary:Abstract Whether TP53, BCL-2 and BAX expressions add independent prognostic information in patients with Ta/T1bladder urothelial carcinoma remains unclear. TP53 overexpression correlated with high tumor grade ( p = 0.004), WHO grading categories (0.045), BAX expression ( p = 0.043) and pathologic stage ( p = 0.05). BCL-2 immunostaining was inverse associated with tumor grade ( p = 0.008). Lack of BAX expression was related to reduced patient’s survival ( p = 0.028). Mortality was higher in patients with BCL-2+/TP53+ ( p = 0.023) or TP53+/BAX− ( p = 0.027) phenotype. BAX and pathologic stage were independent predictors of progression-free and overall survival, respectively. Therefore, BAX expression might be relevant in patient’s prognosis.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2006.10.011