Early Exercise Training Normalizes Myofilament Function and Attenuates Left Ventricular Pump Dysfunction in Mice With a Large Myocardial Infarction

• Published in: Circulation research 2007-04, Vol.100 (7), p.1079-1088
• Main Authors: de Waard, Monique C, van der Velden, Jolanda, Bito, Virginie, Ozdemir, Semir, Biesmans, Liesbeth, Boontje, Nicky M, Dekkers, Dick H.W, Schoonderwoerd, Kees, Schuurbiers, Hans C.H, de Crom, Rini, Stienen, Ger J.M, Sipido, Karin R, Lamers, Jos M.J, Duncker, Dirk J
• Format: Article
• Language: English
• Subjects: Actin Cytoskeleton - metabolism; Animals; Biological and medical sciences; Blotting, Western; Cardiology. Vascular system; Coronary heart disease; Cyclic AMP - metabolism; Female; Fundamental and applied biological sciences. Psychology; Heart; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Male; Medical sciences; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocardial Infarction - mortality; Myocardial Infarction - physiopathology; Myocytes, Cardiac - metabolism; Permeability; Phosphorylation; Physical Conditioning, Animal; Proteins - metabolism; Severity of Illness Index; Time Factors; Ventricular Dysfunction, Left - physiopathology; Ventricular Function, Left; Ventricular Remodeling; Vertebrates: cardiovascular system
• ISSN: 0009-7330; 1524-4571
• DOI: 10.1161/01.RES.0000262655.16373.37

The extent and mechanism of the cardiac benefit of early exercise training following myocardial infarction (MI) is incompletely understood, but may involve blunting of abnormalities in Ca-handling and myofilament function. Consequently, we investigated the effects of 8-weeks of voluntary exercise, started early after a large MI, on left ventricular (LV) remodeling and dysfunction in the mouse. Exercise had no effect on survival, MI size or LV dimensions, but improved LV fractional shortening from 8±1 to 12±1%, and LVdP/dtP30 from 5295±207 to 5794±207 mm Hg/s (both P