Potential of dendritic cell immunotherapy for relapse after allogeneic hematopoietic stem cell transplantation, shown by WT1 peptide‐ and keyhole limpet hemocyanin‐pulsed, donor‐derived dendritic cell vaccine for acute myeloid leukemia

Induction of leukemia‐specific immune responses is a promising treatment for acute myeloid leukemia. A 58‐year‐old woman received Wilms' tumor 1 (WT1) peptide‐ and keyhole limpet hemocyanin (KLH)‐pulsed, donor‐derived dendritic cell (DC) vaccination for AML relapse after allogeneic stem cell tr...

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Bibliographic Details
Published in:American journal of hematology 2008-04, Vol.83 (4), p.315-317
Main Authors: Kitawaki, Toshio, Kadowaki, Norimitsu, Kondo, Tadakazu, Ishikawa, Takayuki, Ichinohe, Tatsuo, Teramukai, Satoshi, Fukushima, Masanori, Kasai, Yasunari, Maekawa, Taira, Uchiyama, Takashi
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Cancer Vaccines - immunology
Cancer Vaccines - therapeutic use
Combined Modality Therapy
Cytarabine - administration & dosage
Daunorubicin - administration & dosage
Dendritic Cells - immunology
Dendritic Cells - transplantation
Disease Progression
Female
Hematologic and hematopoietic diseases
Hematopoietic Stem Cell Transplantation
Hemocyanins - immunology
Humans
Immunosuppressive Agents - therapeutic use
Immunotherapy, Active
Leukemia, Myelomonocytic, Acute - therapy
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Living Donors
Medical sciences
Middle Aged
Peptide Fragments - immunology
Phosphoproteins - immunology
Salvage Therapy
Siblings
Transplantation, Homologous
Viral Matrix Proteins - immunology
WT1 Proteins - immunology
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Summary:Induction of leukemia‐specific immune responses is a promising treatment for acute myeloid leukemia. A 58‐year‐old woman received Wilms' tumor 1 (WT1) peptide‐ and keyhole limpet hemocyanin (KLH)‐pulsed, donor‐derived dendritic cell (DC) vaccination for AML relapse after allogeneic stem cell transplantation. The vaccination induced immune responses to the naïve antigen KLH, whereas definitive immune responses to WT1 were not detected. Leukemia gradually progressed despite of vaccination. This study indicates that DC vaccination can induce an antigen‐specific immune response in a patient after allogeneic stem cell transplantation, thus representing a viable strategy to induce antigen‐specific immune responses in such patients. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.21127