Layered peptide arrays: a diverse technique for antibody screening of clinical samples

The layered peptide array (LPA) is a recently developed technique designed to measure antibody levels in a multiplex, high-throughput manner. LPAs can assess antibody presence either in fluid samples or from tissues while maintaining the two-dimensional orientation of the life science platform. In t...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2007-03, Vol.1098 (1), p.451-453
Main Authors: Gannot, Gallya, Tangrea, Michael A, Chuaqui, Rodrigo F, Gillespie, John W, Emmert-Buck, Michael R
Format: Article
Language:English
Subjects:
Antibodies - analysis
Antibodies - blood
Enzyme-Linked Immunosorbent Assay
Humans
Immunohistochemistry
Peptides - analysis
Peptides - blood
Protein Array Analysis
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Summary:The layered peptide array (LPA) is a recently developed technique designed to measure antibody levels in a multiplex, high-throughput manner. LPAs can assess antibody presence either in fluid samples or from tissues while maintaining the two-dimensional orientation of the life science platform. In this manuscript, we evaluated and assessed the performance of the LPA platform, focusing on throughput capability, sensitivity, and specificity of the assay in several different systems.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1384.041