The particles of the embryonic cerebrospinal fluid: How could they influence brain development?

Abstract During brain development, the embryonic cerebrospinal fluid (E-CSF) allows brain expansion and promotes neuroepithelial cell survival, proliferation or differentiation. Previous analyses of E-CSF content have revealed a high protein concentration and the presence of membranous particles. Th...

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Bibliographic Details
Published in:Brain research bulletin 2008-03, Vol.75 (2), p.289-294
Main Authors: Bachy, Isabelle, Kozyraki, Renata, Wassef, Marion
Format: Article
Language:English
Subjects:
Amino Acids - metabolism
Animals
Apolipoproteins A - genetics
Apolipoproteins A - metabolism
Brain
Brain - drug effects
Brain - embryology
Brain - ultrastructure
Cerebrospinal fluid
Cerebrospinal Fluid - chemistry
Cerebrospinal Fluid - metabolism
Chick Embryo
Development
Embryo, Mammalian
Embryonic Development - drug effects
Gene Expression Regulation, Developmental - drug effects
Growth factors
Mice
Microscopy, Electron, Transmission
Morphogens
Nerve Tissue Proteins - metabolism
Neuroepithelial Cells - drug effects
Neuroepithelial Cells - physiology
Neuroepithelial Cells - ultrastructure
Neurology
Particles
Particulate Matter - pharmacology
Signal Transduction - drug effects
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Summary:Abstract During brain development, the embryonic cerebrospinal fluid (E-CSF) allows brain expansion and promotes neuroepithelial cell survival, proliferation or differentiation. Previous analyses of E-CSF content have revealed a high protein concentration and the presence of membranous particles. The role of these particles in the E-CSF remains poorly investigated. In this study we showed that the E-CSF contains at least two pools of particles: lipoproteins and exosome-like particles. We showed that these two populations of particles strongly interact with neuropithelial cells via an endocytic process, which display regional specificity along the developing neural tube. Finally, we explore and discuss the possibility that these interactions may influence brain development through the regulation of morphogen and growth factor signaling transduction.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2007.10.010