Major Uropathogenic Escherichia coli Strain Isolated in the Northwest of England Identified by Multilocus Sequence Typing

A total of 88 uropathogenic Escherichia coli isolates, including 68 isolates from urine and 20 isolates from blood, were characterized by multilocus sequence typing (MLST). MLST has identified an important genetic lineage of E. coli, designated sequence type 131 (ST-131), represented by 52 of these...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2008-03, Vol.46 (3), p.1076-1080
Main Authors: Lau, Siu Ha, Reddy, Suganya, Cheesbrough, John, Bolton, Frederick J, Willshaw, Geraldine, Cheasty, Tom, Fox, Andrew J, Upton, Mathew
Format: Article
Language:English
Subjects:
Bacteremia - epidemiology
Bacteremia - microbiology
Bacterial Typing Techniques
Bacteriology
Biological and medical sciences
Blood - microbiology
Cephalosporin Resistance
England - epidemiology
Escherichia coli
Escherichia coli - classification
Escherichia coli - genetics
Escherichia coli - isolation & purification
Escherichia coli Infections - epidemiology
Escherichia coli Infections - microbiology
Escherichia coli Proteins - genetics
Escherichia coli Proteins - isolation & purification
Fundamental and applied biological sciences. Psychology
Humans
Microbiology
Miscellaneous
Sequence Analysis, DNA
Urinary Tract Infections - epidemiology
Urinary Tract Infections - microbiology
Urine - microbiology
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Summary:A total of 88 uropathogenic Escherichia coli isolates, including 68 isolates from urine and 20 isolates from blood, were characterized by multilocus sequence typing (MLST). MLST has identified an important genetic lineage of E. coli, designated sequence type 131 (ST-131), represented by 52 of these isolates, 51 of which were resistant to extended-spectrum cephalosporins. ST-131 appears to be a drug-resistant uropathogenic strain of E. coli responsible for causing urinary tract infections and bacteremia and is widely disseminated among both community and hospital patients from different geographical areas in the northwest of England. Application of MLST has helped to define the population biology which may underpin the epidemiology of pathogenic E. coli strains. The portability of MLST allows the accurate monitoring of this antibiotic-resistant uropathogenic strain of E. coli and will enhance surveillance for this important group of organisms.
ISSN:0095-1137
1098-660X
1098-5530
DOI:10.1128/JCM.02065-07