Sesquiterpenes from Ulmus davidiana var. japonica with the inhibitory effects on lipopolysaccharide-induced nitric oxide production

Investigation of antiinflammatory constituents of the stem and root barks of Ulmus davidiana var. japonica resulted in the isolation of three guaiane type sesquiterpenes, torilin, 1-hydroxytorilin, together with a new derivative, (1β, 7β, 8β, 10β)-1,8,11-trihydroxy-4-guaien-8-angeloyl-3-one named 1-...

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Bibliographic Details
Published in:Fitoterapia 2007-04, Vol.78 (3), p.196-199
Main Authors: Kim, Young Choong, Lee, Mi Kyeong, Sung, Sang Hyun, Kim, Seung Hyun
Format: Article
Language:English
Subjects:
1-Hydroxytorilin A
Animals
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Antiinflammatory activity
Biological and medical sciences
Cells, Cultured
Dose-Response Relationship, Drug
General pharmacology
Guaianes
Lipopolysaccharides
Medical sciences
Mice
Nitric Oxide - antagonists & inhibitors
Nitric Oxide - biosynthesis
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Roots
Plant Stems
Sesquiterpenes - administration & dosage
Sesquiterpenes - pharmacology
Sesquiterpenes - therapeutic use
Ulmus
Ulmus davidiana var. japonica
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Summary:Investigation of antiinflammatory constituents of the stem and root barks of Ulmus davidiana var. japonica resulted in the isolation of three guaiane type sesquiterpenes, torilin, 1-hydroxytorilin, together with a new derivative, (1β, 7β, 8β, 10β)-1,8,11-trihydroxy-4-guaien-8-angeloyl-3-one named 1-hydroxytorilin A. All the three sesquiterpenes inhibited lipopolysaccharide-induced nitric oxide production in murine microglial BV2 cells.
ISSN:0367-326X
DOI:10.1016/j.fitote.2006.11.013