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The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves
Moringa oleifera is used in Thai traditional medicine as cardiotonic. Recent studies demonstrated its hypocholesterolaemic effect. However, to be clinically useful, more scientific data are needed. Aim of the Study: We investigated the antioxidant, hypolipidaemic and antiatherosclerotic activities o...
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| Published in: | Journal of ethnopharmacology 2008-03, Vol.116 (3), p.439-446 |
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| creator | Chumark, Pilaipark Khunawat, Panya Sanvarinda, Yupin Phornchirasilp, Srichan Morales, Noppawan Phumala Phivthong-ngam, Laddawal Ratanachamnong, Piyanee Srisawat, Supath Pongrapeeporn, Klai-upsorn S. |
| description | Moringa oleifera is used in Thai traditional medicine as cardiotonic. Recent studies demonstrated its hypocholesterolaemic effect. However, to be clinically useful, more scientific data are needed.
Aim of the Study: We investigated the antioxidant, hypolipidaemic and antiatherosclerotic activities of
Moringa oleifera leaf extract.
Materials and Methods: Scavenging activity of the extract on 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH), and the inhibitory effect on Cu
2+-induced low-density lipoprotein (LDL) oxidation were determined in
in vitro experiment. The effects of the extract on cholesterol levels, conjugated diene (CD) and thiobarbituric acid reactive substances (TBARS) and plaque formations in cholesterol-fed rabbits were investigated.
Results: We found that in scavenging DPPH radicals the extract and Trolox
® had IC
50 of 78.15
±
0.92 and 2.14
±
0.12
μg/ml, respectively. The extract significantly (
P
<
0.05) prolonged the lag-time of CD formation and inhibited TBARS formation in both
in vitro and
ex vivo experiments in a dose-dependent manner. In hypercholesterol-fed rabbits, at 12 weeks of treatment, it significantly (
P
<
0.05) lowered the cholesterol levels and reduced the atherosclerotic plaque formation to about 50 and 86%, respectively. These effects were at degrees comparable to those of simvastatin.
Conclusions: The results indicate that this plant possesses antioxidant, hypolipidaemic and antiatherosclerotic activities and has therapeutic potential for the prevention of cardiovascular diseases. |
| doi_str_mv | 10.1016/j.jep.2007.12.010 |
| format | article |
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Aim of the Study: We investigated the antioxidant, hypolipidaemic and antiatherosclerotic activities of
Moringa oleifera leaf extract.
Materials and Methods: Scavenging activity of the extract on 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH), and the inhibitory effect on Cu
2+-induced low-density lipoprotein (LDL) oxidation were determined in
in vitro experiment. The effects of the extract on cholesterol levels, conjugated diene (CD) and thiobarbituric acid reactive substances (TBARS) and plaque formations in cholesterol-fed rabbits were investigated.
Results: We found that in scavenging DPPH radicals the extract and Trolox
® had IC
50 of 78.15
±
0.92 and 2.14
±
0.12
μg/ml, respectively. The extract significantly (
P
<
0.05) prolonged the lag-time of CD formation and inhibited TBARS formation in both
in vitro and
ex vivo experiments in a dose-dependent manner. In hypercholesterol-fed rabbits, at 12 weeks of treatment, it significantly (
P
<
0.05) lowered the cholesterol levels and reduced the atherosclerotic plaque formation to about 50 and 86%, respectively. These effects were at degrees comparable to those of simvastatin.
Conclusions: The results indicate that this plant possesses antioxidant, hypolipidaemic and antiatherosclerotic activities and has therapeutic potential for the prevention of cardiovascular diseases.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2007.12.010</identifier><identifier>PMID: 18249514</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>animal models ; Animals ; Antiatherosclerotic ; antiatherosclerotic activity ; antioxidant activity ; Antioxidants - pharmacology ; aqueous solutions ; Atherosclerosis - drug therapy ; Atherosclerosis - prevention & control ; Biological and medical sciences ; Biphenyl Compounds ; blood lipids ; Body Weight - drug effects ; cholesteremic effect ; cholesterol ; Cholesterol - blood ; Cholesterol, Dietary - administration & dosage ; Cholesterol, Dietary - pharmacology ; dosage ; dose response ; free radical scavengers ; free radicals ; General pharmacology ; Humans ; Hypolipidaemic ; Hypolipidemic Agents - pharmacology ; in vitro studies ; leaves ; lipemic effect ; lipid peroxidation ; Lipids - blood ; Lipoproteins, LDL - metabolism ; low density lipoprotein ; Male ; Medical sciences ; medicinal plants ; medicinal properties ; Moringa oleifera ; Moringa oleifera - chemistry ; Moringa oleifera Lam. leaves ; Moringaceae ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Picrates - analysis ; plant extracts ; Plant Extracts - pharmacology ; Plant Leaves - chemistry ; Rabbits ; Simvastatin - pharmacology ; Thiobarbituric Acid Reactive Substances - analysis ; Vitamin E - pharmacology ; Water - chemistry</subject><ispartof>Journal of ethnopharmacology, 2008-03, Vol.116 (3), p.439-446</ispartof><rights>2007 Elsevier Ireland Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-4a7cbb9ca24b16284ad8b19adf86081e60fa0dca3529dfa5d86a4ff9685a38df3</citedby><cites>FETCH-LOGICAL-c471t-4a7cbb9ca24b16284ad8b19adf86081e60fa0dca3529dfa5d86a4ff9685a38df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20199521$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18249514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chumark, Pilaipark</creatorcontrib><creatorcontrib>Khunawat, Panya</creatorcontrib><creatorcontrib>Sanvarinda, Yupin</creatorcontrib><creatorcontrib>Phornchirasilp, Srichan</creatorcontrib><creatorcontrib>Morales, Noppawan Phumala</creatorcontrib><creatorcontrib>Phivthong-ngam, Laddawal</creatorcontrib><creatorcontrib>Ratanachamnong, Piyanee</creatorcontrib><creatorcontrib>Srisawat, Supath</creatorcontrib><creatorcontrib>Pongrapeeporn, Klai-upsorn S.</creatorcontrib><title>The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Moringa oleifera is used in Thai traditional medicine as cardiotonic. Recent studies demonstrated its hypocholesterolaemic effect. However, to be clinically useful, more scientific data are needed.
Aim of the Study: We investigated the antioxidant, hypolipidaemic and antiatherosclerotic activities of
Moringa oleifera leaf extract.
Materials and Methods: Scavenging activity of the extract on 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH), and the inhibitory effect on Cu
2+-induced low-density lipoprotein (LDL) oxidation were determined in
in vitro experiment. The effects of the extract on cholesterol levels, conjugated diene (CD) and thiobarbituric acid reactive substances (TBARS) and plaque formations in cholesterol-fed rabbits were investigated.
Results: We found that in scavenging DPPH radicals the extract and Trolox
® had IC
50 of 78.15
±
0.92 and 2.14
±
0.12
μg/ml, respectively. The extract significantly (
P
<
0.05) prolonged the lag-time of CD formation and inhibited TBARS formation in both
in vitro and
ex vivo experiments in a dose-dependent manner. In hypercholesterol-fed rabbits, at 12 weeks of treatment, it significantly (
P
<
0.05) lowered the cholesterol levels and reduced the atherosclerotic plaque formation to about 50 and 86%, respectively. These effects were at degrees comparable to those of simvastatin.
Conclusions: The results indicate that this plant possesses antioxidant, hypolipidaemic and antiatherosclerotic activities and has therapeutic potential for the prevention of cardiovascular diseases.</description><subject>animal models</subject><subject>Animals</subject><subject>Antiatherosclerotic</subject><subject>antiatherosclerotic activity</subject><subject>antioxidant activity</subject><subject>Antioxidants - pharmacology</subject><subject>aqueous solutions</subject><subject>Atherosclerosis - drug therapy</subject><subject>Atherosclerosis - prevention & control</subject><subject>Biological and medical sciences</subject><subject>Biphenyl Compounds</subject><subject>blood lipids</subject><subject>Body Weight - drug effects</subject><subject>cholesteremic effect</subject><subject>cholesterol</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, Dietary - administration & dosage</subject><subject>Cholesterol, Dietary - pharmacology</subject><subject>dosage</subject><subject>dose response</subject><subject>free radical scavengers</subject><subject>free radicals</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Hypolipidaemic</subject><subject>Hypolipidemic Agents - pharmacology</subject><subject>in vitro studies</subject><subject>leaves</subject><subject>lipemic effect</subject><subject>lipid peroxidation</subject><subject>Lipids - blood</subject><subject>Lipoproteins, LDL - metabolism</subject><subject>low density lipoprotein</subject><subject>Male</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Moringa oleifera</subject><subject>Moringa oleifera - chemistry</subject><subject>Moringa oleifera Lam. leaves</subject><subject>Moringaceae</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Picrates - analysis</subject><subject>plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves - chemistry</subject><subject>Rabbits</subject><subject>Simvastatin - pharmacology</subject><subject>Thiobarbituric Acid Reactive Substances - analysis</subject><subject>Vitamin E - pharmacology</subject><subject>Water - chemistry</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp9kc9u1DAQxiMEokvhAbiAL3AiwXacxBEnVPFPWsSB9mxN7HHXqyQOtndpn4MXxmFXcOPisWd-38gzX1E8Z7RilLVv99Uel4pT2lWMV5TRB8WGyY6XXdPVD4sNrTtZyk6wi-JJjHuaQSbo4-KCSS76holN8et6h8TN5OhS8ARmQ_AuP47rPTl_50yOZAl-wZAcxjdkd7_40S25gJPTfyQrCmmHwUc95jOteZ1cbpolxFvyExKG3DqFnF8TX31w8y0QP6KzGIBsYarIiHDE-LR4ZGGM-OwcL4ubjx-urz6X22-fvly935ZadCyVAjo9DL0GLgbWcinAyIH1YKxsqWTYUgvUaKgb3hsLjZEtCGv7VjZQS2Pry-L1qW8e78cBY1KTixrHEWb0h6g6WkvRsz6D7ATqPGEMaNUS3AThXjGqVifUXmUn1OqEYlxlJ7Lmxbn5YZjQ_FOcV5-BV2cAoobRBpi1i385TlnfN5xl7uWJs-AV3IbM3HzP1ZrSbC0XK_HuRGBe1tFhUFE7nDUaF1AnZbz7z0d_A2dks0I</recordid><startdate>20080328</startdate><enddate>20080328</enddate><creator>Chumark, Pilaipark</creator><creator>Khunawat, Panya</creator><creator>Sanvarinda, Yupin</creator><creator>Phornchirasilp, Srichan</creator><creator>Morales, Noppawan Phumala</creator><creator>Phivthong-ngam, Laddawal</creator><creator>Ratanachamnong, Piyanee</creator><creator>Srisawat, Supath</creator><creator>Pongrapeeporn, Klai-upsorn S.</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080328</creationdate><title>The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves</title><author>Chumark, Pilaipark ; Khunawat, Panya ; Sanvarinda, Yupin ; Phornchirasilp, Srichan ; Morales, Noppawan Phumala ; Phivthong-ngam, Laddawal ; Ratanachamnong, Piyanee ; Srisawat, Supath ; Pongrapeeporn, Klai-upsorn S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-4a7cbb9ca24b16284ad8b19adf86081e60fa0dca3529dfa5d86a4ff9685a38df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>animal models</topic><topic>Animals</topic><topic>Antiatherosclerotic</topic><topic>antiatherosclerotic activity</topic><topic>antioxidant activity</topic><topic>Antioxidants - pharmacology</topic><topic>aqueous solutions</topic><topic>Atherosclerosis - drug therapy</topic><topic>Atherosclerosis - prevention & control</topic><topic>Biological and medical sciences</topic><topic>Biphenyl Compounds</topic><topic>blood lipids</topic><topic>Body Weight - drug effects</topic><topic>cholesteremic effect</topic><topic>cholesterol</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, Dietary - administration & dosage</topic><topic>Cholesterol, Dietary - pharmacology</topic><topic>dosage</topic><topic>dose response</topic><topic>free radical scavengers</topic><topic>free radicals</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Hypolipidaemic</topic><topic>Hypolipidemic Agents - pharmacology</topic><topic>in vitro studies</topic><topic>leaves</topic><topic>lipemic effect</topic><topic>lipid peroxidation</topic><topic>Lipids - blood</topic><topic>Lipoproteins, LDL - metabolism</topic><topic>low density lipoprotein</topic><topic>Male</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Moringa oleifera</topic><topic>Moringa oleifera - chemistry</topic><topic>Moringa oleifera Lam. leaves</topic><topic>Moringaceae</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Picrates - analysis</topic><topic>plant extracts</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves - chemistry</topic><topic>Rabbits</topic><topic>Simvastatin - pharmacology</topic><topic>Thiobarbituric Acid Reactive Substances - analysis</topic><topic>Vitamin E - pharmacology</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chumark, Pilaipark</creatorcontrib><creatorcontrib>Khunawat, Panya</creatorcontrib><creatorcontrib>Sanvarinda, Yupin</creatorcontrib><creatorcontrib>Phornchirasilp, Srichan</creatorcontrib><creatorcontrib>Morales, Noppawan Phumala</creatorcontrib><creatorcontrib>Phivthong-ngam, Laddawal</creatorcontrib><creatorcontrib>Ratanachamnong, Piyanee</creatorcontrib><creatorcontrib>Srisawat, Supath</creatorcontrib><creatorcontrib>Pongrapeeporn, Klai-upsorn S.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chumark, Pilaipark</au><au>Khunawat, Panya</au><au>Sanvarinda, Yupin</au><au>Phornchirasilp, Srichan</au><au>Morales, Noppawan Phumala</au><au>Phivthong-ngam, Laddawal</au><au>Ratanachamnong, Piyanee</au><au>Srisawat, Supath</au><au>Pongrapeeporn, Klai-upsorn S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2008-03-28</date><risdate>2008</risdate><volume>116</volume><issue>3</issue><spage>439</spage><epage>446</epage><pages>439-446</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Moringa oleifera is used in Thai traditional medicine as cardiotonic. Recent studies demonstrated its hypocholesterolaemic effect. However, to be clinically useful, more scientific data are needed.
Aim of the Study: We investigated the antioxidant, hypolipidaemic and antiatherosclerotic activities of
Moringa oleifera leaf extract.
Materials and Methods: Scavenging activity of the extract on 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH), and the inhibitory effect on Cu
2+-induced low-density lipoprotein (LDL) oxidation were determined in
in vitro experiment. The effects of the extract on cholesterol levels, conjugated diene (CD) and thiobarbituric acid reactive substances (TBARS) and plaque formations in cholesterol-fed rabbits were investigated.
Results: We found that in scavenging DPPH radicals the extract and Trolox
® had IC
50 of 78.15
±
0.92 and 2.14
±
0.12
μg/ml, respectively. The extract significantly (
P
<
0.05) prolonged the lag-time of CD formation and inhibited TBARS formation in both
in vitro and
ex vivo experiments in a dose-dependent manner. In hypercholesterol-fed rabbits, at 12 weeks of treatment, it significantly (
P
<
0.05) lowered the cholesterol levels and reduced the atherosclerotic plaque formation to about 50 and 86%, respectively. These effects were at degrees comparable to those of simvastatin.
Conclusions: The results indicate that this plant possesses antioxidant, hypolipidaemic and antiatherosclerotic activities and has therapeutic potential for the prevention of cardiovascular diseases.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>18249514</pmid><doi>10.1016/j.jep.2007.12.010</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2008-03, Vol.116 (3), p.439-446 |
| issn | 0378-8741 1872-7573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70384919 |
| source | ScienceDirect Journals |
| subjects | animal models Animals Antiatherosclerotic antiatherosclerotic activity antioxidant activity Antioxidants - pharmacology aqueous solutions Atherosclerosis - drug therapy Atherosclerosis - prevention & control Biological and medical sciences Biphenyl Compounds blood lipids Body Weight - drug effects cholesteremic effect cholesterol Cholesterol - blood Cholesterol, Dietary - administration & dosage Cholesterol, Dietary - pharmacology dosage dose response free radical scavengers free radicals General pharmacology Humans Hypolipidaemic Hypolipidemic Agents - pharmacology in vitro studies leaves lipemic effect lipid peroxidation Lipids - blood Lipoproteins, LDL - metabolism low density lipoprotein Male Medical sciences medicinal plants medicinal properties Moringa oleifera Moringa oleifera - chemistry Moringa oleifera Lam. leaves Moringaceae Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Picrates - analysis plant extracts Plant Extracts - pharmacology Plant Leaves - chemistry Rabbits Simvastatin - pharmacology Thiobarbituric Acid Reactive Substances - analysis Vitamin E - pharmacology Water - chemistry |
| title | The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves |
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