A role for microRNAs in the development of the immune system and in the pathogenesis of cancer

Abstract MicroRNAs are a growing class of endogenous small non-coding RNAs that regulate gene expression by binding to target messenger RNAs and inducing translational repression, cleavage or destabilization of the target. Because each miRNA potentially can regulate expression of a distinct set of g...

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Bibliographic Details
Published in:Seminars in cancer biology 2008-04, Vol.18 (2), p.79-88
Main Authors: Kanellopoulou, Chryssa, Monticelli, Silvia
Format: Article
Language:English
Subjects:
Animals
Cancer
Gene Regulatory Networks - physiology
Gene Targeting
Genes, Tumor Suppressor - physiology
Hematology, Oncology and Palliative Medicine
Hematopoiesis
Hematopoietic System - metabolism
Hematopoietic System - physiology
Humans
Immune System - embryology
Immune System - growth & development
MicroRNA
MicroRNAs - genetics
MicroRNAs - metabolism
MicroRNAs - physiology
Models, Biological
Neoplasms - diagnosis
Neoplasms - genetics
Prognosis
Proliferation
Proto-Oncogenes - physiology
RNA Interference
RNA Processing, Post-Transcriptional - physiology
Signal Transduction
Targets
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Summary:Abstract MicroRNAs are a growing class of endogenous small non-coding RNAs that regulate gene expression by binding to target messenger RNAs and inducing translational repression, cleavage or destabilization of the target. Because each miRNA potentially can regulate expression of a distinct set of genes, it is conceivable that the differential expression of different miRNAs might profoundly influence the repertoire of genes that are expressed during development, differentiation or disease. Here, we provide background on the biogenesis and function of miRNAs, and discuss how miRNA-mediated regulation can influence tumorigenesis as well as normal development and function of cells of the immune system.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2008.01.002