Hormonal axes in obesity: cause or effect?

Several endocrine changes have been described in the obesity state. The corticotropic axis is hyperresponsive and there is enhancement of hormonal clearance, but cortisol levels are within the normal range. It is important to characterize a pseudo-Cushing in obesity. Leptin seems to be a permissive...

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Bibliographic Details
Published in:Arquivos brasileiros de endocrinologia e metabologia 2007-02, Vol.51 (1), p.34-41
Main Authors: Lordelo, Roberta A, Mancini, Marcio C, Cercato, Cíntia, Halpern, Alfredo
Format: Article
Language:Portuguese
Subjects:
Adrenocorticotropic Hormone - metabolism
Endocrine Glands - metabolism
Gonadotropins, Pituitary - metabolism
Growth Hormone - metabolism
Hormones - metabolism
Humans
Hypothalamo-Hypophyseal System - metabolism
Insulin Resistance - physiology
Leptin - metabolism
Obesity - metabolism
Obesity - physiopathology
Thyrotropin - metabolism
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Summary:Several endocrine changes have been described in the obesity state. The corticotropic axis is hyperresponsive and there is enhancement of hormonal clearance, but cortisol levels are within the normal range. It is important to characterize a pseudo-Cushing in obesity. Leptin seems to be a permissive hormone for the beginning of puberty. In adults, gonadotropines are normal, and hyperandrogenism and hyperestrogenism are found. In women, insulin resistance has a central role in polycystic ovarian syndrome (POS), which is associated to ovarian hyperandrogenemia. In obese subjects, growth hormone (GH) is generally low and IGF1 is normal. Thyroid function is commonly normal in obese subjects.
ISSN:0004-2730
DOI:10.1590/S0004-27302007000100007