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Simultaneous Investigation of the Influence of Topography and Charge on Protein Adsorption Using Artificial Nanopatterns

The combined influence of surface topography and charge of a polymer surface on the adsorption of the protein avidin has been investigated. Atomic force microscopy contact mode imaging and charge writing were used to create defined topographical roughness and electrostatic charge patterns on the sur...

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Bibliographic Details
Published in:Langmuir 2008-03, Vol.24 (6), p.2284-2287
Main Authors: Blanco, E. Macarena, Horton, Michael A, Mesquida, Patrick
Format: Article
Language:English
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Summary:The combined influence of surface topography and charge of a polymer surface on the adsorption of the protein avidin has been investigated. Atomic force microscopy contact mode imaging and charge writing were used to create defined topographical roughness and electrostatic charge patterns on the surface of polystyrene. Increased avidin adsorption was found on nanometer-size topographical patterns, but the adsorption remained unaffected by electrostatic patterns.
ISSN:0743-7463
1520-5827
DOI:10.1021/la702957f