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Myeloperoxidase as a Measure of Polymorphonuclear Leukocyte Response in Inflammatory Status Around Immediately and Delayed Loaded Dental Implants: A Randomized Controlled Clinical Trial
ABSTRACT Background: As well as gingival crevicular fluid (GCF), peri‐implant sulcus fluid (PISF) may have a potential diagnostic value for the early identification of metabolic and destructive processes. Purpose: The aim of this study was to analyze the potential impact of inflammation and loading...
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| Published in: | Clinical implant dentistry and related research 2008-03, Vol.10 (1), p.30-39 |
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| cites | cdi_FETCH-LOGICAL-c4048-c44f2317c2ed0cbfe90a5117e3c43184b976d43c3e1cb9ce4edd67d6e11b46393 |
| container_end_page | 39 |
| container_issue | 1 |
| container_start_page | 30 |
| container_title | Clinical implant dentistry and related research |
| container_volume | 10 |
| creator | Güncü, Güliz N. Tözüm, Tolga F. Güncü, M. Barış Yamalik, Nermin Tümer, Celal Karabulut, Erdem Kilinç, Kamer |
| description | ABSTRACT
Background: As well as gingival crevicular fluid (GCF), peri‐implant sulcus fluid (PISF) may have a potential diagnostic value for the early identification of metabolic and destructive processes.
Purpose: The aim of this study was to analyze the potential impact of inflammation and loading on PISF myeloperoxidase (MPO) levels, in comparison with GCF.
Materials and Methods: A total of 220 sites, dental implant (immediately [IL] or delayed loaded [DL]), and natural tooth, either healthy/noninflamed or gingivitis/inflamed, were classified. Clinical parameters were recorded, and GCF/PISF samples were obtained. GCF/PISF MPO levels were spectrophotometrically determined.
Results: Clinical parameters demonstrated increases with the presence of gingival/peri‐implant inflammation. Total MPO levels were higher at inflamed tooth and implant sites compared to noninflamed/healthy sites (p |
| doi_str_mv | 10.1111/j.1708-8208.2007.00058.x |
| format | article |
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Background: As well as gingival crevicular fluid (GCF), peri‐implant sulcus fluid (PISF) may have a potential diagnostic value for the early identification of metabolic and destructive processes.
Purpose: The aim of this study was to analyze the potential impact of inflammation and loading on PISF myeloperoxidase (MPO) levels, in comparison with GCF.
Materials and Methods: A total of 220 sites, dental implant (immediately [IL] or delayed loaded [DL]), and natural tooth, either healthy/noninflamed or gingivitis/inflamed, were classified. Clinical parameters were recorded, and GCF/PISF samples were obtained. GCF/PISF MPO levels were spectrophotometrically determined.
Results: Clinical parameters demonstrated increases with the presence of gingival/peri‐implant inflammation. Total MPO levels were higher at inflamed tooth and implant sites compared to noninflamed/healthy sites (p < .05). Although they did not reach a significance level, inflamed IL sites had higher total MPO levels than inflamed DL sites (p = .401). Gingival index and total MPO levels exhibited significant correlations (p < .05).
Conclusion: Using implants and natural teeth in the same study design, the findings of the present study support the close relationship between MPO production and inflammation, and may speculate a potential for loading of dental implants, contributing to the MPO content of PISF.</description><identifier>ISSN: 1523-0899</identifier><identifier>EISSN: 1708-8208</identifier><identifier>DOI: 10.1111/j.1708-8208.2007.00058.x</identifier><identifier>PMID: 18335584</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biomarkers - analysis ; Dental Abutments ; Dental Implantation, Endosseous - methods ; Dental Implants ; Dentistry ; Female ; Follow-Up Studies ; Gingiva - enzymology ; Gingival Crevicular Fluid - enzymology ; Gingivitis - enzymology ; Humans ; inflammation ; loading ; Male ; Middle Aged ; myeloperoxidase ; natural tooth ; Neutrophils - physiology ; Periodontal Index ; Periodontitis - enzymology ; Peroxidase - analysis ; Spectrophotometry ; Time Factors</subject><ispartof>Clinical implant dentistry and related research, 2008-03, Vol.10 (1), p.30-39</ispartof><rights>2007, Copyright the Authors</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4048-c44f2317c2ed0cbfe90a5117e3c43184b976d43c3e1cb9ce4edd67d6e11b46393</citedby><cites>FETCH-LOGICAL-c4048-c44f2317c2ed0cbfe90a5117e3c43184b976d43c3e1cb9ce4edd67d6e11b46393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18335584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Güncü, Güliz N.</creatorcontrib><creatorcontrib>Tözüm, Tolga F.</creatorcontrib><creatorcontrib>Güncü, M. Barış</creatorcontrib><creatorcontrib>Yamalik, Nermin</creatorcontrib><creatorcontrib>Tümer, Celal</creatorcontrib><creatorcontrib>Karabulut, Erdem</creatorcontrib><creatorcontrib>Kilinç, Kamer</creatorcontrib><title>Myeloperoxidase as a Measure of Polymorphonuclear Leukocyte Response in Inflammatory Status Around Immediately and Delayed Loaded Dental Implants: A Randomized Controlled Clinical Trial</title><title>Clinical implant dentistry and related research</title><addtitle>Clin Implant Dent Relat Res</addtitle><description>ABSTRACT
Background: As well as gingival crevicular fluid (GCF), peri‐implant sulcus fluid (PISF) may have a potential diagnostic value for the early identification of metabolic and destructive processes.
Purpose: The aim of this study was to analyze the potential impact of inflammation and loading on PISF myeloperoxidase (MPO) levels, in comparison with GCF.
Materials and Methods: A total of 220 sites, dental implant (immediately [IL] or delayed loaded [DL]), and natural tooth, either healthy/noninflamed or gingivitis/inflamed, were classified. Clinical parameters were recorded, and GCF/PISF samples were obtained. GCF/PISF MPO levels were spectrophotometrically determined.
Results: Clinical parameters demonstrated increases with the presence of gingival/peri‐implant inflammation. Total MPO levels were higher at inflamed tooth and implant sites compared to noninflamed/healthy sites (p < .05). Although they did not reach a significance level, inflamed IL sites had higher total MPO levels than inflamed DL sites (p = .401). Gingival index and total MPO levels exhibited significant correlations (p < .05).
Conclusion: Using implants and natural teeth in the same study design, the findings of the present study support the close relationship between MPO production and inflammation, and may speculate a potential for loading of dental implants, contributing to the MPO content of PISF.</description><subject>Adult</subject><subject>Biomarkers - analysis</subject><subject>Dental Abutments</subject><subject>Dental Implantation, Endosseous - methods</subject><subject>Dental Implants</subject><subject>Dentistry</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gingiva - enzymology</subject><subject>Gingival Crevicular Fluid - enzymology</subject><subject>Gingivitis - enzymology</subject><subject>Humans</subject><subject>inflammation</subject><subject>loading</subject><subject>Male</subject><subject>Middle Aged</subject><subject>myeloperoxidase</subject><subject>natural tooth</subject><subject>Neutrophils - physiology</subject><subject>Periodontal Index</subject><subject>Periodontitis - enzymology</subject><subject>Peroxidase - analysis</subject><subject>Spectrophotometry</subject><subject>Time Factors</subject><issn>1523-0899</issn><issn>1708-8208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqNkc9u1DAQxiMEoqXwCsgnbhvsOH8cxGW1pduVtgWVRRwtx54Ib504tR2x6Zv17XDYVbliS54Zze8bW_6SBBGckrg-7lNSYbZgGWZphnGVYowLlh5eJOfPjZcxLzK6wKyuz5I33u8xzggpyevkjDBKi4Ll58nTzQTGDuDsQSvhAQmPBLoB4UcHyLbomzVTZ93wy_ajNCAc2sJ4b-UUAN2BH2wfRbpHm741outEsG5C34MIo0dLZ8deoU3XgdIigJmQiPUlGDGBQlsrFMxlH4SJ1GBEH_wntER3EbOdfozdle2Ds8bMqdG9lhHdOS3M2-RVK4yHd6d4kfy4-rJbXS-2X9eb1XK7kDnOWTzzNqOkkhkoLJsWaiwKQiqgMqeE5U1dlSqnkgKRTS0hB6XKSpVASJOXtKYXyYfj3MHZhxF84J32Ekx8LNjR8wrTGscdQXYEpbPeO2j54HQn3MQJ5rNtfM9nd_jsDp9t439t44cofX-6Y2ziX_0TnnyKwOcj8FsbmP57MF9tLmMS5YujXPsAh2e5cPe8rGhV8J-3a17srta3dXHNKf0Dmj65aA</recordid><startdate>200803</startdate><enddate>200803</enddate><creator>Güncü, Güliz N.</creator><creator>Tözüm, Tolga F.</creator><creator>Güncü, M. Barış</creator><creator>Yamalik, Nermin</creator><creator>Tümer, Celal</creator><creator>Karabulut, Erdem</creator><creator>Kilinç, Kamer</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200803</creationdate><title>Myeloperoxidase as a Measure of Polymorphonuclear Leukocyte Response in Inflammatory Status Around Immediately and Delayed Loaded Dental Implants: A Randomized Controlled Clinical Trial</title><author>Güncü, Güliz N. ; Tözüm, Tolga F. ; Güncü, M. Barış ; Yamalik, Nermin ; Tümer, Celal ; Karabulut, Erdem ; Kilinç, Kamer</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4048-c44f2317c2ed0cbfe90a5117e3c43184b976d43c3e1cb9ce4edd67d6e11b46393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Biomarkers - analysis</topic><topic>Dental Abutments</topic><topic>Dental Implantation, Endosseous - methods</topic><topic>Dental Implants</topic><topic>Dentistry</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gingiva - enzymology</topic><topic>Gingival Crevicular Fluid - enzymology</topic><topic>Gingivitis - enzymology</topic><topic>Humans</topic><topic>inflammation</topic><topic>loading</topic><topic>Male</topic><topic>Middle Aged</topic><topic>myeloperoxidase</topic><topic>natural tooth</topic><topic>Neutrophils - physiology</topic><topic>Periodontal Index</topic><topic>Periodontitis - enzymology</topic><topic>Peroxidase - analysis</topic><topic>Spectrophotometry</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Güncü, Güliz N.</creatorcontrib><creatorcontrib>Tözüm, Tolga F.</creatorcontrib><creatorcontrib>Güncü, M. Barış</creatorcontrib><creatorcontrib>Yamalik, Nermin</creatorcontrib><creatorcontrib>Tümer, Celal</creatorcontrib><creatorcontrib>Karabulut, Erdem</creatorcontrib><creatorcontrib>Kilinç, Kamer</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical implant dentistry and related research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Güncü, Güliz N.</au><au>Tözüm, Tolga F.</au><au>Güncü, M. Barış</au><au>Yamalik, Nermin</au><au>Tümer, Celal</au><au>Karabulut, Erdem</au><au>Kilinç, Kamer</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myeloperoxidase as a Measure of Polymorphonuclear Leukocyte Response in Inflammatory Status Around Immediately and Delayed Loaded Dental Implants: A Randomized Controlled Clinical Trial</atitle><jtitle>Clinical implant dentistry and related research</jtitle><addtitle>Clin Implant Dent Relat Res</addtitle><date>2008-03</date><risdate>2008</risdate><volume>10</volume><issue>1</issue><spage>30</spage><epage>39</epage><pages>30-39</pages><issn>1523-0899</issn><eissn>1708-8208</eissn><abstract>ABSTRACT
Background: As well as gingival crevicular fluid (GCF), peri‐implant sulcus fluid (PISF) may have a potential diagnostic value for the early identification of metabolic and destructive processes.
Purpose: The aim of this study was to analyze the potential impact of inflammation and loading on PISF myeloperoxidase (MPO) levels, in comparison with GCF.
Materials and Methods: A total of 220 sites, dental implant (immediately [IL] or delayed loaded [DL]), and natural tooth, either healthy/noninflamed or gingivitis/inflamed, were classified. Clinical parameters were recorded, and GCF/PISF samples were obtained. GCF/PISF MPO levels were spectrophotometrically determined.
Results: Clinical parameters demonstrated increases with the presence of gingival/peri‐implant inflammation. Total MPO levels were higher at inflamed tooth and implant sites compared to noninflamed/healthy sites (p < .05). Although they did not reach a significance level, inflamed IL sites had higher total MPO levels than inflamed DL sites (p = .401). Gingival index and total MPO levels exhibited significant correlations (p < .05).
Conclusion: Using implants and natural teeth in the same study design, the findings of the present study support the close relationship between MPO production and inflammation, and may speculate a potential for loading of dental implants, contributing to the MPO content of PISF.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18335584</pmid><doi>10.1111/j.1708-8208.2007.00058.x</doi><tpages>10</tpages></addata></record> |
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| ispartof | Clinical implant dentistry and related research, 2008-03, Vol.10 (1), p.30-39 |
| issn | 1523-0899 1708-8208 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Biomarkers - analysis Dental Abutments Dental Implantation, Endosseous - methods Dental Implants Dentistry Female Follow-Up Studies Gingiva - enzymology Gingival Crevicular Fluid - enzymology Gingivitis - enzymology Humans inflammation loading Male Middle Aged myeloperoxidase natural tooth Neutrophils - physiology Periodontal Index Periodontitis - enzymology Peroxidase - analysis Spectrophotometry Time Factors |
| title | Myeloperoxidase as a Measure of Polymorphonuclear Leukocyte Response in Inflammatory Status Around Immediately and Delayed Loaded Dental Implants: A Randomized Controlled Clinical Trial |
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