Interaction of Nanoparticles with Lipid Membrane

A nanoscale range of surface feature curvatures where lipid membranes lose integrity and form pores has been found experimentally. The pores were experimentally observed in the l-α-dimyristoyl phosphatidylcholine membrane around 1.2−22 nm polar nanoparticles deposited on mica surface. Lipid bilayer...

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Bibliographic Details
Published in:Nano letters 2008-03, Vol.8 (3), p.941-944
Main Authors: Roiter, Yuri, Ornatska, Maryna, Rammohan, Aravind R, Balakrishnan, Jitendra, Heine, David R, Minko, Sergiy
Format: Article
Language:English
Subjects:
Chemical synthesis methods
Condensed matter: structure, mechanical and thermal properties
Cross-disciplinary physics: materials science
rheology
Exact sciences and technology
Lipid Bilayers - chemistry
Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties
Materials science
Methods of nanofabrication
Microscopy, Atomic Force
Nanocrystalline materials
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Nanoscale materials and structures: fabrication and characterization
Physics
Surfaces and interfaces
thin films and whiskers (structure and nonelectronic properties)
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Summary:A nanoscale range of surface feature curvatures where lipid membranes lose integrity and form pores has been found experimentally. The pores were experimentally observed in the l-α-dimyristoyl phosphatidylcholine membrane around 1.2−22 nm polar nanoparticles deposited on mica surface. Lipid bilayer envelops or closely follows surface features with the curvatures outside of that region. This finding provides essential information for the understanding of nanoparticle−lipid membrane interaction, cytotoxicity, preparation of biomolecular templates and supported lipid membranes on rough and patterned surfaces.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl080080l