Hepatocyte growth factor induction of macrophage chemoattractant protein-1 and osteophyte-inducing factors in osteoarthritis

In osteoarthritis (OA), hepatocyte growth factor (HGF) is supposed to play a role in cartilage repair. Because the development of osteophytes is a major characteristic of OA and thought to be part of an attempted repair process, the purpose of this study was to determine whether HGF may be involved...

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Bibliographic Details
Published in:Journal of orthopaedic research 2007-05, Vol.25 (5), p.569-577
Main Authors: Dankbar, Berno, Neugebauer, Katja, Wunrau, Christina, Tibesku, Carsten O., Skwara, Adrian, Pap, Thomas, Fuchs-Winkelmann, Susanne
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antigens, CD - metabolism
Antigens, Differentiation, Myelomonocytic - metabolism
Cartilage - metabolism
Cartilage - pathology
Cells, Cultured
Chemokine CCL2 - metabolism
Chondrocytes - pathology
Chondrocytes - physiology
Female
Femur - metabolism
Femur - pathology
Hepatocyte Growth Factor - metabolism
HGF
Humans
Macrophages - metabolism
Macrophages - pathology
Male
MCP-1
Middle Aged
Monocytes - metabolism
osteoarthritis
Osteoarthritis - diagnostic imaging
Osteoarthritis - pathology
Osteoarthritis - physiopathology
osteophyte
Proto-Oncogene Proteins c-met - metabolism
Radiography
Severity of Illness Index
Synovial Fluid - metabolism
Synovial Membrane - metabolism
Synovial Membrane - pathology
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Summary:In osteoarthritis (OA), hepatocyte growth factor (HGF) is supposed to play a role in cartilage repair. Because the development of osteophytes is a major characteristic of OA and thought to be part of an attempted repair process, the purpose of this study was to determine whether HGF may be involved in osteophyte formation. HGF levels in synovial fluids from 41 patients assessed by enzyme immunosorbant assay were correlated with disease severity and osteophyte formation, evaluated by anteroposterior weight‐bearing radiographs. Detection of HGF, c‐Met, and CD68 in cartilage and synovial tissues was assessed by immunohistochemistry. Effects of HGF on the secretion of TGF‐β1 and BMP‐2 by chondrocytes, fibroblast‐like synovial cells (FLS), and macrophages as well as HGF‐induced secretion of MCP‐1 by FLS and chondrocytes were determined by ELISA. HGF was detected in all synovial fluids and concentrations correlated highly with disease severity and osteophyte formation (p 
ISSN:0736-0266
1554-527X
DOI:10.1002/jor.20338