How valuable is measurement of peripheral blood natural killer cells at the time of abortion?

Increased peripheral blood natural killer (NK) cells are associated to immune-mediated abortion, but their diagnostic value when measured at the time of miscarriage is unknown. In women with therapeutic (A = 79) or elective (C = 34) pregnancy termination, the NK-cell percentage was measured before a...

Full description

Saved in:
Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2008-04, Vol.59 (4), p.306-315
Main Authors: Paparistidis, Nikolaos, Papadopoulou, Chryssa, Chioti, Athanassia, Papaioannou, Demetrios, Tsekoura, Christina, Keramitsoglou, Theodora, Kontopoulou-Antonopoulou, Virginia, Agapitos, Emmanouel, Balafoutas, Christos, Varla-Leftherioti, Marighoula
Format: Article
Language:English
Subjects:
Abortion, Missed - blood
Abortion, Missed - diagnosis
Abortion, Missed - immunology
Abortion, Missed - pathology
Adult
Antibodies, Monoclonal - immunology
CD56 Antigen - analysis
Chorionic Villi - immunology
Chorionic Villi - pathology
Female
Humans
Immunohistochemistry
Keratins - analysis
Keratins - immunology
Killer Cells, Natural - cytology
Killer Cells, Natural - immunology
Lymphocyte Count
Predictive Value of Tests
Receptors, IgG - analysis
Time Factors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Increased peripheral blood natural killer (NK) cells are associated to immune-mediated abortion, but their diagnostic value when measured at the time of miscarriage is unknown. In women with therapeutic (A = 79) or elective (C = 34) pregnancy termination, the NK-cell percentage was measured before and 5 days after curettage. Additionally, immune-mediated lesions (scored 0-3) and CD56(+) and CD16(+) decidual NKs (scored 1-3) were detected on the abortion material. Aborters differed from controls in histological scores (P = 0.000) and in NK percentage (>12%) only in the measurement 5 days after the operation (P = 0.038). In comparison to histological lesions, NK measurement was found to have sensitivity 70%, specificity 73.68%, positive prognostic value 89.39% and negative prognostic value 43.75%. An Increased NK-cell percentage 5 days after the pregnancy termination could be a marker of immune aetiology of miscarriage, as the probability of an aborter with NK >12% to have an immune-mediated abortion is almost 90%.
ISSN:1046-7408
DOI:10.1111/j.1600-0897.2007.00547.x