Trichinella spiralis: Modulation of experimental autoimmune encephalomyelitis in DA rats

Helminth infection has a potent systemic immunomodulatory effect on the host immune response, which also affects the development of autoimmune diseases. We investigated the dose-dependent influence of Trichinella spiralis infection on experimental autoimmune encephalomyelitis (EAE). Our model of con...

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Bibliographic Details
Published in:Experimental parasitology 2008-04, Vol.118 (4), p.641-647
Main Authors: Gruden-Movsesijan, A., Ilic, N., Mostarica-Stojkovic, M., Stosic-Grujicic, S., Milic, M., Sofronic-Milosavljevic, Lj
Format: Article
Language:English
Subjects:
Animals
autoimmune diseases
Biological and medical sciences
dark agouti
Dark Agouti rats
disease severity
dose response
Dose-Response Relationship, Immunologic
EAE
encephalitis
Encephalomyelitis, Autoimmune, Experimental - complications
Encephalomyelitis, Autoimmune, Experimental - immunology
experimental autoimmune encephalomyelitis
Female
Fundamental and applied biological sciences. Psychology
host immunomodulation
host-parasite relationships
immune response
Life cycle. Host-agent relationship. Pathogenesis
mixed infection
muscle larvae
NBL
new born larvae
Parasite infection
Protozoa
Rats
Rats, Wistar
Severity of Illness Index
Spinal Cord - pathology
T. spiralis muscle larvae, L1 stage
Trichinella spiralis
Trichinella spiralis - immunology
Trichinellosis - complications
Trichinellosis - immunology
trichinosis
TSL1
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Summary:Helminth infection has a potent systemic immunomodulatory effect on the host immune response, which also affects the development of autoimmune diseases. We investigated the dose-dependent influence of Trichinella spiralis infection on experimental autoimmune encephalomyelitis (EAE). Our model of concomitant T. spiralis infection and EAE demonstrates that established infection of Dark Agouti (DA) rats with the parasite causes amelioration of the clinical course of induced EAE in a dose-dependent way. Infection with T. spiralis L1 stage muscle larvae (TSL1) reduced the severity of the autoimmune disease as judged by lower maximal clinical score, cumulative index, duration of illness and degree of mononuclear cell infiltration in T. spiralis infected animals compared to control, EAE-induced group. This study provides a valuable model of worm infection to investigate helminth-induced regulatory mechanisms for optimal benefit to the host.
ISSN:0014-4894
1090-2449
DOI:10.1016/j.exppara.2007.12.003