The Treatment with Antibody of TNF-α Reduces the Inflammation, Necrosis and Fibrosis in the Non-alcoholic Steatohepatitis Induced by Methionine- and Choline-deficient Diet

To assess the effects of anti-TNF-α antibody (infliximab) in experimental steatohepatitis induced by methionine- and choline-deficient (MCD) diet. The study included thirty rats. One group received normal rat food, and two groups received MCD diet. The treatment group received a single dose intra-pe...

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Bibliographic Details
Published in:Inflammation 2008-04, Vol.31 (2), p.91-98
Main Authors: Koca, Suleyman Serdar, Bahcecioglu, Ibrahim Halil, Poyrazoglu, Orhan Kursat, Ozercan, Ibrahim Hanifi, Sahin, Kazim, Ustundag, Bilal
Format: Article
Language:English
Subjects:
Actin
Actins - metabolism
Alanine Transaminase - blood
Animals
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - pharmacology
Antibodies
Antibodies, Monoclonal - administration & dosage
Antibodies, Monoclonal - pharmacology
Aspartate Aminotransferases - blood
Biomedical and Life Sciences
Biomedicine
Choline
Choline Deficiency - complications
Choline Deficiency - drug therapy
Choline Deficiency - pathology
Degeneration
Diet
Disease Models, Animal
Fatty Liver - etiology
Fatty Liver - pathology
Fatty Liver - prevention & control
Fibrosis
Hepatitis - etiology
Hepatitis - pathology
Hepatitis - prevention & control
Immunology
Inflammation
Infliximab
Injections, Intraperitoneal
Internal Medicine
Liver - drug effects
Liver - enzymology
Liver - pathology
Liver Cirrhosis - etiology
Liver Cirrhosis - pathology
Liver Cirrhosis - prevention & control
Male
Malondialdehyde - metabolism
Methionine
Methionine - deficiency
Monoclonal antibodies
Necrosis
Nutrient deficiency
Pathology
Pharmacology/Toxicology
Rats
Rheumatology
Steatosis
Time Factors
Transforming Growth Factor beta1 - metabolism
Transforming growth factor-b1
Tumor Necrosis Factor-alpha - antagonists & inhibitors
Tumor Necrosis Factor-alpha - immunology
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-α
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Summary:To assess the effects of anti-TNF-α antibody (infliximab) in experimental steatohepatitis induced by methionine- and choline-deficient (MCD) diet. The study included thirty rats. One group received normal rat food, and two groups received MCD diet. The treatment group received a single dose intra-peritoneal infliximab (4 mg/kg), at week 8. MCD diet increased levels of AST, ALT, TNF-α, TGF-β 1 , tissue and plasma MDA ( p  
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-007-9053-z