Effects of pravastatin in murine collagen-induced arthritis

Here we evaluated whether 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have beneficial effects for collagen-induced arthritis (CIA). DBA/1 mice were immunized with bovine type-II collagen and administered 100 mg/kg of pravastatin interperitoneally. We measured the effects of...

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Bibliographic Details
Published in:Rheumatology international 2007-05, Vol.27 (7), p.631-639
Main Authors: Yamagata, Toshiaki, Kinoshita, Koji, Nozaki, Yuji, Sugiyama, Masafumi, Ikoma, Shinya, Funauchi, Masanori
Format: Article
Language:English
Subjects:
Animals
Arthritis, Experimental - drug therapy
Arthritis, Experimental - immunology
Arthritis, Experimental - pathology
Aspartate Aminotransferases - blood
Blood Urea Nitrogen
Chemokine CCL2 - genetics
Chemokine CCL2 - metabolism
Chemokines - metabolism
Collagen
Collagen Type II - immunology
Corticosterone - blood
Creatine Kinase - blood
Creatinine - blood
Disease Models, Animal
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - immunology
Leukocytes, Mononuclear - metabolism
Male
Mice
Mice, Inbred DBA
Pravastatin - pharmacology
RNA, Messenger - metabolism
Synovial Membrane - immunology
Synovial Membrane - pathology
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Summary:Here we evaluated whether 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have beneficial effects for collagen-induced arthritis (CIA). DBA/1 mice were immunized with bovine type-II collagen and administered 100 mg/kg of pravastatin interperitoneally. We measured the effects of pravastatin for CIA including infiltration of macrophages at the synovial membrane and production of anti-type-II collagen antibodies and cytokines. Adverse reactions of pravastatin were also measured. The pravastatin-treated mice had delayed onset of CIA compared with the controls. The involvement of inflammatory cells in the synovial membrane and the expression of monocyte chemotactic protein-1 (MCP-1) mRNA in the joint were reduced. Moreover, some cytokines (TNF-alpha, IL-6, IFN-gamma) and MCP-1 levels in the supernatants of spleen cells cultured with pravastatin decreased. Meanwhile, adverse reactions of pravastatin, such as peritonitis, were not detected. Pravastatin may have good prospects for treating some anti-inflammatory effects on human rheumatoid arthritis.
ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-006-0270-9