The cardiovascular effects of adrenaline, dobutamine and milrinone in rabbits using pressure-volume loops and guinea pig isolated atrial tissue

This study evaluated the effects of milrinone, adrenaline and dobutamine with pressure-volume loops and isolated atrial tissue. Agonist dose-response curves to incremental drug infusions were acquired in 11 anesthetised rabbits using pressure-volume loops and preload recruitable stroke work indicate...

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Bibliographic Details
Published in:Anaesthesia and intensive care 2007-04, Vol.35 (2), p.180-188
Main Authors: ROYSE, C. F, ROYSE, A. G, ROHRLACH, R, WRIGHT, C. E, ANGUS, J. A
Format: Article
Language:English
Subjects:
Adrenergic Agonists - pharmacology
Adrenergic beta-Agonists - pharmacology
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
Blood Pressure - drug effects
Cardiotonic Agents - pharmacology
Cardiovascular system
Chemical properties
Dobutamine
Dobutamine - pharmacology
Dose-Response Relationship, Drug
Epinephrine
Epinephrine - pharmacology
Guinea Pigs
Health aspects
Heart - drug effects
Heart Atria - drug effects
Heart Rate - drug effects
Male
Medical sciences
Milrinone
Milrinone - pharmacology
Myocardial Contraction - drug effects
Organ Culture Techniques
Rabbits
Vascular Resistance - drug effects
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Summary:This study evaluated the effects of milrinone, adrenaline and dobutamine with pressure-volume loops and isolated atrial tissue. Agonist dose-response curves to incremental drug infusions were acquired in 11 anesthetised rabbits using pressure-volume loops and preload recruitable stroke work indicated contractility. Agonist concentration-response curves were completed in eight guinea pig isolated atria, for effects on atrial rate and force. Adrenaline and dobutamine increased contractility (P = 0.006 and 0.044), whereas milrinone did not (P = 0.895). Only adrenaline increased myocardial stiffness (P < 0.001). Milrinone decreased vascular resistance (P < 0.001) and elicited the greatest fall in mean arterial pressure (P < 0.001) and increased ejection fraction (P < 0.001). Adrenaline decreased heart rate (P < 0.001), whereas dobutamine and milrinone increased it (P = 0.006 and 0.011). Milrinone increased the force of left atrial contraction, but its inotropic effect was weak and significantly less than with dobutamine and adrenaline (P < 0.001). Adrenaline acted as an inoconstrictor, dobutamine an inodilator and milrinone predominantly a vasodilator
ISSN:0310-057X
1448-0271
DOI:10.1177/0310057X0703500207