Bacteriocin-like inhibitory substances from Campylobacter spp

Twenty-five Campylobacter isolates were screened for production of antimicrobial substances using a deferred antagonism assay. Sixteen isolates showed activity against either Staphylococcus aureus, Salmonella enterica serovar Enteritidis or Candida albicans. The inhibitory activity was sensitive to...

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Bibliographic Details
Published in:Antonie van Leeuwenhoek 2008-05, Vol.93 (4), p.435-436
Main Authors: Workman, Suzanne Nicole, Been, Floyd E, Crawford, Simera R, Lavoie, Marc C
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - antagonists & inhibitors
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - pharmacology
Antibiosis
Bacillus subtilis
Bacteria
Bacteria - drug effects
Bacteriocins - antagonists & inhibitors
Bacteriocins - metabolism
Bacteriocins - pharmacology
Bacteriology
Biological and medical sciences
Biomedical and Life Sciences
Campylobacter
Campylobacter - metabolism
Campylobacter - physiology
Candida albicans
Drug resistance
Fundamental and applied biological sciences. Psychology
Life Sciences
Medical Microbiology
Metabolism. Enzymes
Microbiology
Micrococcus luteus
Plant Sciences
Salmonella enterica
Short Communication
Soil Science & Conservation
Staphylococcus aureus
Streptococcus
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Summary:Twenty-five Campylobacter isolates were screened for production of antimicrobial substances using a deferred antagonism assay. Sixteen isolates showed activity against either Staphylococcus aureus, Salmonella enterica serovar Enteritidis or Candida albicans. The inhibitory activity was sensitive to treatment with pronase E, trypsin and pepsin, suggesting that the antimicrobial compound(s) are proteinaceous. Activity spectra of isolates included S. aureus, Micrococcus luteus, Streptococcus sp., Bacillus subtilis, a drug-resistant clinical isolate of S. aureus and one isolate of C. albicans. Producing isolates showed cross-immunity and inhibitory activity was only observed on solid media. The findings of this study suggest that Campylobacter produces proteinaceous inhibitory substances.
ISSN:0003-6072
1572-9699
DOI:10.1007/s10482-007-9208-9