Malignant fibrous histiocytoma of the mandible in the context of a traumatic Marjolin's ulcer

Abstract We present a rare manifestation of a chronic mandibular wound with a traumatic diathesis. A 38-year-old male patient sought medical consultation because of painless swelling in the mandibular symphysis and mild paresthesia of the lower lip. He mentioned a history of physical trauma to the m...

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Bibliographic Details
Published in:Journal of tissue viability 2008-05, Vol.17 (2), p.38-43
Main Authors: Mesgarzadeh, Ali Hossein, Farahani, Ramin Mostofi Zadeh, Treister, Nathaniel
Format: Article
Language:English
Subjects:
Accidental Falls
Adult
Advanced Basic Science
Biopsy
Causality
Cell Transformation, Neoplastic
Chronic Disease
Critical Care
Fatal Outcome
Histiocytoma, Malignant Fibrous - diagnosis
Histiocytoma, Malignant Fibrous - etiology
Histiocytoma, Malignant Fibrous - therapy
Humans
Male
Malignant fibrous histiocytoma
Mandible
Mandibular Injuries - complications
Mandibular Neoplasms - diagnosis
Mandibular Neoplasms - etiology
Mandibular Neoplasms - therapy
Mandibular Prosthesis Implantation
Marjolin's ulcer
Neoplasm Recurrence, Local
Nursing
Physical trauma
Radiography, Panoramic
Radiotherapy, Adjuvant
Rare Diseases
Skin Ulcer - complications
Storiform-pleomorphic
Tomography, X-Ray Computed
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Summary:Abstract We present a rare manifestation of a chronic mandibular wound with a traumatic diathesis. A 38-year-old male patient sought medical consultation because of painless swelling in the mandibular symphysis and mild paresthesia of the lower lip. He mentioned a history of physical trauma to the mandibular symphysis 12 months ago. The radiographic evaluation and CT scan showed gross destruction of bone leading to a well-defined radiolucent lesion without any sclerosing margins. The histological examination revealed numerous spindle-shaped fibroblasts arranged in a fascicular pattern and scattered multinucleated and mononuclear cells with bizarre nuclei throughout the lesion. Moderate nuclear pleomorphism was evident with few mitotic cells. The lesion was diagnosed as a malignant fibrous histiocytoma of storiform-pleomorphic type based on the previous descriptions. After surgical removal of the lesion and the adjacent tissues and reconstruction, the patient was referred to a radiotherapist for continuation of treatment. Despite this therapy, the lesion recurred after a year, and prior to the second operation, the patient died as a result of brain involvement.
ISSN:0965-206X
DOI:10.1016/j.jtv.2007.09.012