Endothelium specific matrilysin (MMP-7) expression in human cancers

Over-expression of matrilysin (MMP-7) is predominantly associated with epithelial (pre)malignant cells. In the present study MMP-7 expression is also found in endothelial cells in various human cancer types. Endothelial MMP-7 was associated with CD34 and/or CD105 expression. These immunohistochemica...

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Published in:Matrix biology 2008-04, Vol.27 (3), p.267-271
Main Authors: Sier, Cornelis F.M., Hawinkels, Lukas J.A.C., Zijlmans, Henry J.M.A.A., Zuidwijk, Kim, de Jonge-Muller, Eveline S.M., Ferreira, Valérie, Hanemaaijer, Roeland, Mulder-Stapel, Adri A., Kenter, Gemma G., Verspaget, Hein W., Gorter, Arko
Format: Article
Language:English
Subjects:
Angiogenesis
Breast
Carcinoma
Carcinoma - enzymology
Cell Line, Tumor
Cervix
Colon
Endothelium - enzymology
Female
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Humans
Matrix metalloproteinase
Matrix Metalloproteinase 7 - biosynthesis
Neoplasm Invasiveness
Neovascularization, Pathologic
Prostate
Spheroids, Cellular - pathology
Stomach
Time Factors
Tissue Distribution
Umbilical Veins - cytology
Uterine Cervical Neoplasms - enzymology
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Summary:Over-expression of matrilysin (MMP-7) is predominantly associated with epithelial (pre)malignant cells. In the present study MMP-7 expression is also found in endothelial cells in various human cancer types. Endothelial MMP-7 was associated with CD34 and/or CD105 expression. These immunohistochemical data were confirmed by RT-PCR on VEGF-stimulated endothelial cells. In addition, MMP-7 was also identified in sprouting endothelial cells in vitro. The potential clinical relevance of endothelial MMP-7 was assessed for cervical cancer patients by evaluating the association with overall survival. In contrast to MMP-7 in malignant epithelial cells, MMP-7 expression in endothelial cells showed a significant association with poor survival (LR 5.12, P = 0.02, n = 30). Our data suggest that MMP-7 is involved in tumor angiogenesis, thereby contributing to malignant growth and hence associated with decreased survival.
ISSN:0945-053X
1569-1802
DOI:10.1016/j.matbio.2007.10.006