Antenatal dexamethasone and renal vascular resistance in preterm infants

Objective:  To compare vascular resistance, renal volume and insulin levels in preterm infants with and without antenatal steroids. Methods:  We studied 61 preterm infants (37 with (group A) and 24 without antecedent of antenatal steroids (group B)). We measured insulin levels at birth in cord blood...

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Published in:Journal of paediatrics and child health 2007-04, Vol.43 (4), p.303-306
Main Authors: Amador-Licona, Norma, Guízar-Mendoza, Juan Manuel, Maciel-Miranda, Jesús Alejandro, Romero-Gutiérrez, Gustavo
Format: Article
Language:English
Subjects:
Adult
antenatal steroid
Dexamethasone - pharmacology
Dexamethasone - therapeutic use
Female
Glucocorticoids - pharmacology
Glucocorticoids - therapeutic use
Humans
Infant, Newborn
Infant, Premature
Insulin - analysis
insulin level
Kidney - blood supply
Male
Mexico
Prenatal Care
preterm infant
Renal Artery - diagnostic imaging
Renal Artery - physiopathology
renal artery resistance
renal volume
Ultrasonography
Vascular Resistance - drug effects
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Summary:Objective:  To compare vascular resistance, renal volume and insulin levels in preterm infants with and without antenatal steroids. Methods:  We studied 61 preterm infants (37 with (group A) and 24 without antecedent of antenatal steroids (group B)). We measured insulin levels at birth in cord blood samples. Ultrasound measurements to evaluate renal arteries resistance index and renal volume were performed during the first 72 h of birth. Results:  Preterm infants from group A tended to have lower weight and gestational age than those from group B. Resistance index in renal arteries was lower in preterm infants with steroid therapy compared with group B (right renal artery 0.73 vs. 0.80; P = 0.001, and left renal artery 0.75 vs. 0.79; P = 0.01, respectively). Renal volume and insulin levels were not different between the groups. In the multiple regression analysis for factors associated with resistance index of renal arteries, only antenatal steroids use was included in the model (R2 = 0.13; P = 0.003 and R2 = 0.10; P = 0.01 for left and right renal arteries, respectively). Conclusion:  Antenatal dexamethasone in preterm infants during the first 72 h of birth seems to decrease resistance index in renal arteries without affecting renal volume and insulin levels.
ISSN:1034-4810
1440-1754
DOI:10.1111/j.1440-1754.2007.01063.x