The identification and characterisation of a novel null HLA-DRB1 allele

Since the introduction of DNA‐based human leukocyte antigen (HLA) typing a number of discrepancies with serological typing have been documented. At the time of submission of this (July 2005 ImMunoGeneTics project (IMGT) project database release) 42 HLA class I and II null alleles had been described...

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Bibliographic Details
Published in:Tissue Antigens 2007-04, Vol.69 (s1), p.58-60
Main Authors: Fidler, S. J., Smith, L. K., Christiansen, F. T.
Format: Article
Language:English
Subjects:
Alleles
Base Sequence
Celiac Disease - genetics
Celiac Disease - immunology
HLA class II
HLA-DR Antigens - genetics
HLA-DRB1 Chains
Humans
Molecular Sequence Data
null alleles
Sequence Homology, Nucleic Acid
sequence-based typing
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Summary:Since the introduction of DNA‐based human leukocyte antigen (HLA) typing a number of discrepancies with serological typing have been documented. At the time of submission of this (July 2005 ImMunoGeneTics project (IMGT) project database release) 42 HLA class I and II null alleles had been described characterised by a lack of expression of cell surface antigen. These null alleles can be accounted for by a number of demonstrated molecular mechanisms including insertion, deletion and point mutation and may lead to a nonsense codon, splicing defect or premature stop codon.
ISSN:0001-2815
1399-0039
DOI:10.1111/j.1399-0039.2006.760_3.x