Predictors of axillary lymph node metastasis in breast cancer: A systematic review

Abstract Aims To review the established and emerging techniques in axillary lymph node prediction and explore their potential impact on clinical practice. To reliably identify patients in whom axillary lymph node surgery, including SLNB, can be safely omitted. Methods Searches of PubMed were made us...

Full description

Saved in:
Bibliographic Details
Published in:European journal of surgical oncology 2007-05, Vol.33 (4), p.409-419
Main Authors: Patani, N.R, Dwek, M.V, Douek, M
Format: Article
Language:English
Subjects:
Axilla
Axillary lymph node
Biomarkers, Tumor - analysis
Breast Neoplasms - pathology
Female
Genetic Markers
Glycoprotein
Glycosylation
Hematology, Oncology and Palliative Medicine
Humans
Lectin
Lymph Node Excision
Lymphatic Metastasis - pathology
Neoplasm Staging
Predictive Value of Tests
Predictor
Prognosis
Risk Factors
Sentinel lymph node
Sentinel Lymph Node Biopsy
Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Aims To review the established and emerging techniques in axillary lymph node prediction and explore their potential impact on clinical practice. To reliably identify patients in whom axillary lymph node surgery, including SLNB, can be safely omitted. Methods Searches of PubMed were made using the search terms “axilla” (or “axillary”), “lymph”, “node” and “predictor” (or “prediction”). Articles from abstracts and reports from meetings were included only when they related directly to previously published work. Findings There are numerous studies in which the predictive utility of biomarkers as determinants of axillary lymph node status have been investigated. Few of these have specifically addressed the attributes of the primary tumour which could offer much potential for the prediction of tumour metastasis to the axillary lymph nodes. Conclusions Currently, no single marker is sufficiently accurate to obviate the need for formal axillary staging using SLNB or axillary clearance.
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2006.09.003